Mitochondria: Sensors and mediators of innate immune receptor signaling

Suzanne M. Cloonan; Augustine M.K. Choi

doi:10.1016/j.mib.2013.05.005

Mitochondria: Sensors and mediators of innate immune receptor signaling

Suzanne M. Cloonan, Augustine M.K. Choi

Research output: Contribution to journal › Review article › peer-review

60 Scopus citations

Abstract

By integrating stress signals with inputs from other cellular organelles, eukaryotic mitochondria are dynamic sensing systems that can confer substantial impact on innate immune signaling in both health and disease. This review highlights recently discovered elements of innate immune receptor signaling (TLR, RLR, NLR, and CLR) associated with mitochondrial function and discusses the role of mitochondria in the initiation and/or manifestation of inflammatory diseases and disorders. We also highlight the role of mitochondria as therapeutic targets for inflammatory disease.

Original language	English (US)
Pages (from-to)	327-338
Number of pages	12
Journal	Current Opinion in Microbiology
Volume	16
Issue number	3
DOIs	https://doi.org/10.1016/j.mib.2013.05.005
State	Published - Jun 2013

ASJC Scopus subject areas

Microbiology
Microbiology (medical)
Infectious Diseases

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10.1016/j.mib.2013.05.005

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title = "Mitochondria: Sensors and mediators of innate immune receptor signaling",

abstract = "By integrating stress signals with inputs from other cellular organelles, eukaryotic mitochondria are dynamic sensing systems that can confer substantial impact on innate immune signaling in both health and disease. This review highlights recently discovered elements of innate immune receptor signaling (TLR, RLR, NLR, and CLR) associated with mitochondrial function and discusses the role of mitochondria in the initiation and/or manifestation of inflammatory diseases and disorders. We also highlight the role of mitochondria as therapeutic targets for inflammatory disease.",

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year = "2013",

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AU - Choi, Augustine M.K.

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N2 - By integrating stress signals with inputs from other cellular organelles, eukaryotic mitochondria are dynamic sensing systems that can confer substantial impact on innate immune signaling in both health and disease. This review highlights recently discovered elements of innate immune receptor signaling (TLR, RLR, NLR, and CLR) associated with mitochondrial function and discusses the role of mitochondria in the initiation and/or manifestation of inflammatory diseases and disorders. We also highlight the role of mitochondria as therapeutic targets for inflammatory disease.

AB - By integrating stress signals with inputs from other cellular organelles, eukaryotic mitochondria are dynamic sensing systems that can confer substantial impact on innate immune signaling in both health and disease. This review highlights recently discovered elements of innate immune receptor signaling (TLR, RLR, NLR, and CLR) associated with mitochondrial function and discusses the role of mitochondria in the initiation and/or manifestation of inflammatory diseases and disorders. We also highlight the role of mitochondria as therapeutic targets for inflammatory disease.

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ER -

Mitochondria: Sensors and mediators of innate immune receptor signaling

Abstract

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