TY - JOUR
T1 - Mitochondria
T2 - Commanders of innate immunity and disease?
AU - Cloonan, Suzanne M.
AU - Choi , Augustine M K
PY - 2012/2/1
Y1 - 2012/2/1
N2 - Mitochondrial dysfunction is associated with the manifestation and origin of a plethora of diseases and disorders. Whilst classically the role of these archetypical 'powerhouses' in many disease phenotypes has been attributed to their ability to regulate cell metabolism and cell death pathways, emerging data posit that mitochondria may also act as powerful initiators and masters of the innate immune response. This new paradigm complements the current mitochondrial dogma, whereby molecules endogenously present on or inside the mitochondria may act as immune regulators in response to stress or pathogens and may also be responsible for the initiation and/or manifestation of chronic inflammation observed in many diseases and disorders.
AB - Mitochondrial dysfunction is associated with the manifestation and origin of a plethora of diseases and disorders. Whilst classically the role of these archetypical 'powerhouses' in many disease phenotypes has been attributed to their ability to regulate cell metabolism and cell death pathways, emerging data posit that mitochondria may also act as powerful initiators and masters of the innate immune response. This new paradigm complements the current mitochondrial dogma, whereby molecules endogenously present on or inside the mitochondria may act as immune regulators in response to stress or pathogens and may also be responsible for the initiation and/or manifestation of chronic inflammation observed in many diseases and disorders.
UR - http://www.scopus.com/inward/record.url?scp=84857062121&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84857062121&partnerID=8YFLogxK
U2 - 10.1016/j.coi.2011.11.001
DO - 10.1016/j.coi.2011.11.001
M3 - Review article
C2 - 22138315
AN - SCOPUS:84857062121
SN - 0952-7915
VL - 24
SP - 32
EP - 40
JO - Current Opinion in Immunology
JF - Current Opinion in Immunology
IS - 1
ER -