TY - JOUR
T1 - MitImpact 3
T2 - Modeling the residue interaction network of the Respiratory Chain subunits
AU - Castellana, Stefano
AU - Biagini, Tommaso
AU - Petrizzelli, Francesco
AU - Parca, Luca
AU - Panzironi, Noemi
AU - Caputo, Viviana
AU - Vescovi, Angelo Luigi
AU - Carella, Massimo
AU - Mazza, Tommaso
N1 - Publisher Copyright:
© 2021 The Author(s) 2020. Published by Oxford University Press on behalf of Nucleic Acids Research.
PY - 2021/1/8
Y1 - 2021/1/8
N2 - Numerous lines of evidence have shown that the interaction between the nuclear and mitochondrial genomes ensures the efficient functioning of the OXPHOS complexes, with substantial implications in bioenergetics, adaptation, and disease. Their interaction is a fascinating and complex trait of the eukaryotic cell that MitImpact explores with its third major release. MitImpact expands its collection of genomic, clinical, and functional annotations of all non-synonymous substitutions of the human mitochondrial genome with new information on putative Compensated Pathogenic Deviations and co-varying amino acid sites of the Respiratory Chain subunits. It further provides evidence of energetic and structural residue compensation by techniques of molecular dynamics simulation. MitImpact is freely accessible at http://mitimpact.css-mendel.it.
AB - Numerous lines of evidence have shown that the interaction between the nuclear and mitochondrial genomes ensures the efficient functioning of the OXPHOS complexes, with substantial implications in bioenergetics, adaptation, and disease. Their interaction is a fascinating and complex trait of the eukaryotic cell that MitImpact explores with its third major release. MitImpact expands its collection of genomic, clinical, and functional annotations of all non-synonymous substitutions of the human mitochondrial genome with new information on putative Compensated Pathogenic Deviations and co-varying amino acid sites of the Respiratory Chain subunits. It further provides evidence of energetic and structural residue compensation by techniques of molecular dynamics simulation. MitImpact is freely accessible at http://mitimpact.css-mendel.it.
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U2 - 10.1093/nar/gkaa1032
DO - 10.1093/nar/gkaa1032
M3 - Article
C2 - 33300029
AN - SCOPUS:85099429166
SN - 0305-1048
VL - 49
SP - D1282-D1288
JO - Nucleic Acids Research
JF - Nucleic Acids Research
IS - D1
ER -