Mitigation of Amphotericin B Nephrotoxicity by Mannitol

Juan J. Olivero, Elias M. Ghafary, Jose Lozano-Mendez, Garabed Eknoyan, Wadi N. Suki

Research output: Contribution to journalArticlepeer-review

43 Scopus citations


Renal transplant recipients are susceptible to a number of fungal infections amenable to therapy with amphotericin B, but azotaemia is an almost invariable sequel to the use of this agent. As intravenous mannitol has been shown to minimize nephrotoxicity induced by amphotericin B in dogs, 4 kidney transplant recipients who had systemic fungal infections were treated with mannitol and amphotericin B. None showed significant reduction in renal function though a mild metabolic acidosis did develop.

Original languageEnglish (US)
Pages (from-to)550-551
Number of pages2
JournalBritish Medical Journal
Issue number5957
StatePublished - Mar 8 1975

ASJC Scopus subject areas

  • Medicine(all)


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