@article{9cd75388c3cb47618028bcc8c87f63a1,
title = "miRNA551b-3p Activates an Oncostatin Signaling Module for the Progression of Triple-Negative Breast Cancer",
abstract = "Parashar et al. demonstrate that the mature microRNA-551b-3p translocates to the nucleus for transcriptional activation of STAT3 gene. As a consequence, miR551b activates an autocrine signaling loop through the upregulation of oncostatin family genes, including oncostatin, and its receptors for the growth and metastasis of triple-negative breast cancer.",
keywords = "IPO8, OSMR, RNAi, STAT3, miR551b, miRNA-therapy, oncostatin",
author = "Deepak Parashar and Anjali Geethadevi and Aure, \{Miriam Ragle\} and Jyotsna Mishra and Jasmine George and Changliang Chen and Mishra, \{Manoj K.\} and Andliena Tahiri and Wei Zhao and Bindu Nair and Yiling Lu and Mangala, \{Lingegowda S.\} and Cristian Rodriguez-Aguayo and Gabriel Lopez-Berestein and Camara, \{Amadou K.S.\} and Mingyu Liang and Rader, \{Janet S.\} and Ramani Ramchandran and Ming You and Sood, \{Anil K.\} and Kristensen, \{Vessela N.\} and Mills, \{Gordon B.\} and Sunila Pradeep and Pradeep Chaluvally-Raghavan",
note = "Funding Information: P.C.-R. is supported by 1R01CA229907, United States; the Ovarian Cancer Research Fund Alliance (OCRFA), United States; the DoD Breast Cancer Research Program (W81XWH-18-1-0024), United States; the Women's Health Research Program (WHRP) at MCW, the American Cancer Society's Institutional Research Grant (ACS-16-183-31), United States; and research funds from MCW's Cancer Center. S.P. is supported by OCRFA, United States; and WHRP funds at MCW. R.R. is supported by 1R01HL112639, 1R01HL120585, and 1R01HL123338, United States. M.Y. is supported by N01CN2015000037, United States; and R01CA134682, United States. G.B.M. is supported by the NCI (2P50CA083639-11, 5P50CA058183-17, and R01CA123219-01), United States, the Stand Up to Cancer/AACR fund (SU2C-AACR-DT0209), United States; the Adelson Medical Research Foundation, United States; and a Komen Promise Grant (KG081694), United States. A.K.S. is supported by the NCI (P50 CA217685, P50 CA098258, R35 CA209904, and UH3 TR000943), United States; the American Cancer Society Research Professor Award, United States; and the Frank McGraw Memorial Chair in Cancer Research, United States. M.R.A. is supported by grant number 2014021, Norway; and A.T. by grant number 2016065 from the South Eastern Norway Health Authority, Norway. The authors acknowledge Dr. Suresh Kumar for his assistance on confocal microscopy. P.C.-R. conceived the study, generated hypotheses, and designed the experiments. D.P. and A.G. performed most of the experiments, including cell cultures, animal experiments, qPCR, 3D morphogenesis, and statistical analyses, and they prepared figures and the manuscript. J.G. B.N. and C.C. prepared stable cells. Y.L. performed RPPA analysis, which G.B.M. supervised. M.R.A. and A.T. performed the bioinformatics analysis, which V.N.K. supervised. M.K.M. and M.L. assisted on the preparation of gene knockout cells. S.P. and P.C.-R. designed the animal experiments. J.M. assisted on confocal microscopy imaging. C.R.-A. L.S.M. G.L.-B. and A.K.S. encapsulated the anti-miRNAs in nanoliposomes for animal studies. M.Y. J.S.R. R.R. and G.B.M. provided scientific feedback and edited the manuscript. P.C.-R. provided scientific direction, established collaborations, prepared the manuscript with D.P. and A.G. and allocated funding for the work. The authors declare no competing interests. Funding Information: P.C.-R. is supported by 1R01CA229907, United States; the Ovarian Cancer Research Fund Alliance (OCRFA), United States; the DoD Breast Cancer Research Program ( W81XWH-18-1-0024 ), United States; the Women{\textquoteright}s Health Research Program (WHRP) at MCW, the American Cancer Society {\textquoteright}s Institutional Research Grant ( ACS-16-183-31 ), United States; and research funds from MCW{\textquoteright}s Cancer Center . S.P. is supported by OCRFA , United States; and WHRP funds at MCW. R.R. is supported by 1R01HL112639 , 1R01HL120585 , and 1R01HL123338 , United States. M.Y. is supported by N01CN2015000037 , United States; and R01CA134682 , United States. G.B.M. is supported by the NCI ( 2P50CA083639-11 , 5P50CA058183-17 , and R01CA123219-01 ), United States, the Stand Up to Cancer / AACR fund ( SU2C-AACR-DT0209 ), United States; the Adelson Medical Research Foundation , United States; and a Komen Promise Grant ( KG081694 ), United States. A.K.S. is supported by the NCI ( P50 CA217685 , P50 CA098258 , R35 CA209904 , and UH3 TR000943 ), United States; the American Cancer Society Research Professor Award, United States; and the Frank McGraw Memorial Chair in Cancer Research, United States . M.R.A. is supported by grant number 2014021 , Norway; and A.T. by grant number 2016065 from the South Eastern Norway Health Authority , Norway. The authors acknowledge Dr. Suresh Kumar for his assistance on confocal microscopy. Publisher Copyright: {\textcopyright} 2019 The Author(s)",
year = "2019",
month = dec,
day = "24",
doi = "10.1016/j.celrep.2019.11.085",
language = "English (US)",
volume = "29",
pages = "4389--4406.e10",
journal = "Cell Reports",
issn = "2211-1247",
publisher = "Cell Press",
number = "13",
}