miR-17–92 explains MYC oncogene addiction

Yulin Li, Stephanie C. Casey, Peter S. Choi, Dean W. Felsher

Research output: Contribution to journalArticle

3 Scopus citations

Abstract

MYC regulates tumorigenesis by coordinating the expression of thousands of genes. We found that MYC appears to regulate the decisions between cell survival versus death and self-renewal versus senescence through the microRNA miR-17–92 cluster. Addiction to the MYC oncogene may therefore in fact be an addiction to miR-17–92.

Original languageEnglish (US)
Article numbere970092
JournalMolecular and Cellular Oncology
Volume1
Issue number4
DOIs
StatePublished - Dec 8 2014

Keywords

  • MYC
  • lymphoma
  • microRNA miR-17-92
  • oncogene addiction

ASJC Scopus subject areas

  • Molecular Medicine
  • Cancer Research

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