Abstract
MYC regulates tumorigenesis by coordinating the expression of thousands of genes. We found that MYC appears to regulate the decisions between cell survival versus death and self-renewal versus senescence through the microRNA miR-17–92 cluster. Addiction to the MYC oncogene may therefore in fact be an addiction to miR-17–92.
Original language | English (US) |
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Article number | e970092 |
Journal | Molecular and Cellular Oncology |
Volume | 1 |
Issue number | 4 |
DOIs | |
State | Published - Dec 8 2014 |
Keywords
- MYC
- lymphoma
- microRNA miR-17-92
- oncogene addiction
ASJC Scopus subject areas
- Molecular Medicine
- Cancer Research