miR-17–92 explains MYC oncogene addiction

Yulin Li; Stephanie C. Casey; Peter S. Choi; Dean W. Felsher

doi:10.4161/23723548.2014.970092

miR-17–92 explains MYC oncogene addiction

Yulin Li, Stephanie C. Casey, Peter S. Choi, Dean W. Felsher

Research output: Contribution to journal › Article › peer-review

4 Scopus citations

Abstract

MYC regulates tumorigenesis by coordinating the expression of thousands of genes. We found that MYC appears to regulate the decisions between cell survival versus death and self-renewal versus senescence through the microRNA miR-17–92 cluster. Addiction to the MYC oncogene may therefore in fact be an addiction to miR-17–92.

Original language	English (US)
Article number	e970092
Journal	Molecular and Cellular Oncology
Volume	1
Issue number	4
DOIs	https://doi.org/10.4161/23723548.2014.970092
State	Published - Dec 8 2014

Keywords

MYC
lymphoma
microRNA miR-17-92
oncogene addiction

ASJC Scopus subject areas

Molecular Medicine
Cancer Research

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10.4161/23723548.2014.970092

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title = "miR-17–92 explains MYC oncogene addiction",

abstract = "MYC regulates tumorigenesis by coordinating the expression of thousands of genes. We found that MYC appears to regulate the decisions between cell survival versus death and self-renewal versus senescence through the microRNA miR-17–92 cluster. Addiction to the MYC oncogene may therefore in fact be an addiction to miR-17–92.",

keywords = "MYC, lymphoma, microRNA miR-17-92, oncogene addiction",

author = "Yulin Li and Casey, {Stephanie C.} and Choi, {Peter S.} and Felsher, {Dean W.}",

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AU - Li, Yulin

AU - Casey, Stephanie C.

AU - Choi, Peter S.

AU - Felsher, Dean W.

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N2 - MYC regulates tumorigenesis by coordinating the expression of thousands of genes. We found that MYC appears to regulate the decisions between cell survival versus death and self-renewal versus senescence through the microRNA miR-17–92 cluster. Addiction to the MYC oncogene may therefore in fact be an addiction to miR-17–92.

AB - MYC regulates tumorigenesis by coordinating the expression of thousands of genes. We found that MYC appears to regulate the decisions between cell survival versus death and self-renewal versus senescence through the microRNA miR-17–92 cluster. Addiction to the MYC oncogene may therefore in fact be an addiction to miR-17–92.

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KW - lymphoma

KW - microRNA miR-17-92

KW - oncogene addiction

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miR-17–92 explains MYC oncogene addiction

Abstract

Keywords

ASJC Scopus subject areas

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