Minimally invasive input function for 2- 18F-fluoro-A-85380 brain PET studies

Paolo Zanotti-Fregonara, Renaud Maroy, Marie Anne Peyronneau, Régine Trebossen, Michel Bottlaender

Research output: Contribution to journalArticlepeer-review

17 Scopus citations


Purpose Quantitative neuroreceptor positron emission tomography (PET) studies often require arterial cannulation to measure input function. While population-based input function (PBIF) would be a less invasive alternative, it has only rarely been used in conjunction with neuroreceptor PET tracers. The aims of this study were (1) to validate the use of PBIF for 2- 18F-fluoro-A-85380 a tracer for nicotinic receptors; (2) to compare the accuracy of measures obtained via PBIF to those obtained via blood-scaled imagederived input function (IDIF) from carotid arteries; and (3) to explore the possibility of using venous instead of arterial samples for both PBIF and IDIF. Methods Ten healthy volunteers underwent a dynamic 2- 18Ffluoro- A-85380 brain PET scan with arterial and, in seven subjects, concurrent venous serial blood sampling. PBIF was obtained by averaging the normalized metabolite-corrected arterial input function and subsequently scaling each curve with individual blood samples. IDIF was obtained from the carotid arteries using a blood-scaling method. Estimated Logan distribution volume (V T) values were compared to the reference values obtained from arterial cannulation. Results For all subjects, PBIF curves scaled with arterial samples were similar in shape and magnitude to the reference arterial input function. The Logan VT ratio was 1.00± 0.05; all subjects had an estimation error <10%. IDIF gave slightly less accurate results (V T ratio 1.03±0.07; eight of ten subjects had an error <10%) . PBIF scaled with venous samples yielded inaccurate results (VT ratio 1.13±0.13; only three of seven subjects had an error <10%) . Due to arteriovenous differences at early time points, IDIF could not be calculated using venous samples. Conclusion PBIF scaled with arterial samples accurately estimates Logan V T for 2- 18F-fluoro-A-85380. Results obtained with PBIF were slightly better than those obtained with IDIF. Due to arteriovenous concentration differences, venous samples cannot be substituted for arterial samples.

Original languageEnglish (US)
Pages (from-to)651-659
Number of pages9
JournalEuropean Journal of Nuclear Medicine and Molecular Imaging
Issue number4
StatePublished - Apr 2012


  • 2- F-Fluoro-A-85380
  • Brain studies with PET
  • Input function

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging


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