TY - JOUR
T1 - Mild and Effective Polymerization of Dopamine on Keratin Films for Innovative Photoactivable and Biocompatible Coated Materials
AU - Posati, Tamara
AU - Ferroni, Claudia
AU - Aluigi, Annalisa
AU - Guerrini, Andrea
AU - Rossi, Francesca
AU - Tatini, Francesca
AU - Ratto, Fulvio
AU - Marras, Emanuela
AU - Gariboldi, Marzia Bruna
AU - Sagnella, Anna
AU - Ruani, Giampiero
AU - Zamboni, Roberto
AU - Varchi, Greta
AU - Sotgiu, Giovanna
N1 - Funding Information:
T.P. and C.F. contributed equally to this work. The authors acknowledge Cariaggi Fine Yarns, S.p.a. for the Merino wool fibers supply; and Franco Corticelli and Vincenzo Ragona for the technical support. The manuscript was written through contributions of all authors. All authors have given approval to the final version of the manuscript.
Publisher Copyright:
© 2018 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Copyright:
Copyright 2018 Elsevier B.V., All rights reserved.
PY - 2018/8
Y1 - 2018/8
N2 - Mussel-inspired polydopamine (PD) coating represents a promising route for constructing functional materials and finely tuning or completely changing their surface properties. In this work, a mild and effective method to realize the deposition of PD on keratin-based films is reported. Reactive oxygen species (ROS), generated by keratin films doped with a photosensitizer, e.g., Azure A (AzA), upon UV–vis and vis-near IR irradiation, are exploited to obtain the PD coating. Interestingly, the use of vis-near IR irradiation leads to an increased production of ROS by AzA resulting in a greater PD deposition. Compared to uncoated keratin films, the PD-keratin coated materials show a granular but homogeneous surface and an increased hydrophilicity, maintaining the ROS generation ability of AzA. This work demonstrates a useful method to effectively and rapidly functionalize with PD materials that are sensitive to temperature, pH and UV light, such as keratin. The proposed strategy allows obtaining new multifunctional biomaterials of potential interest in tissue engineering and drug delivery; in particular, the use of PD-keratin films for near IR laser bonding of ophthalmic tissue, which is a representative case in wound healing purpose, is shown.
AB - Mussel-inspired polydopamine (PD) coating represents a promising route for constructing functional materials and finely tuning or completely changing their surface properties. In this work, a mild and effective method to realize the deposition of PD on keratin-based films is reported. Reactive oxygen species (ROS), generated by keratin films doped with a photosensitizer, e.g., Azure A (AzA), upon UV–vis and vis-near IR irradiation, are exploited to obtain the PD coating. Interestingly, the use of vis-near IR irradiation leads to an increased production of ROS by AzA resulting in a greater PD deposition. Compared to uncoated keratin films, the PD-keratin coated materials show a granular but homogeneous surface and an increased hydrophilicity, maintaining the ROS generation ability of AzA. This work demonstrates a useful method to effectively and rapidly functionalize with PD materials that are sensitive to temperature, pH and UV light, such as keratin. The proposed strategy allows obtaining new multifunctional biomaterials of potential interest in tissue engineering and drug delivery; in particular, the use of PD-keratin films for near IR laser bonding of ophthalmic tissue, which is a representative case in wound healing purpose, is shown.
KW - keratin-based materials
KW - photosensitizers
KW - photothermal activity
KW - polydopamine coatings
KW - surface modification
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U2 - 10.1002/mame.201700653
DO - 10.1002/mame.201700653
M3 - Article
AN - SCOPUS:85047632805
VL - 303
JO - Macromolecular Materials and Engineering
JF - Macromolecular Materials and Engineering
SN - 1438-7492
IS - 8
M1 - 1700653
ER -