Microspaeropsis olivacea keratitis and consecutive endophthalmitis

Chirag V. Shah, Dan B. Jones, Eric Holz

Research output: Contribution to journalArticlepeer-review

18 Scopus citations


PURPOSE: To report a case of fungal keratitis with consecutive endophthalmitis caused by Microsphaeropsis olivacea. METHODS: Case report. RESULTS: A 51-year-old man developed fungal keratitis and consecutive endophthalmitis after sustaining a penetrating injury to the right eye. Cultures of the aqueous humor yielded M. olivacea. Infection resolved after intraocular fungal debridement, intravitreous amphotericin B, and aggressive topical natamycin and oral fluconazole. Persistent, low-grade smoldering corneal and intraocular inflammation required topical corticosteroid therapy. CONCLUSION: M. olivacea is an exceedingly rare ocular pathogen. The intraocular portion of the infection responded quickly to intravitreal antifungal treatment; however, the course was prolonged by smoldering corneal inflammation. Prompt recognition of intraocular spread and aggressive treatment may be beneficial in fungal infections caused by unusual organisms with uncertain virulence.

Original languageEnglish (US)
Pages (from-to)142-143
Number of pages2
JournalAmerican Journal of Ophthalmology
Issue number1
StatePublished - Jan 16 2001

ASJC Scopus subject areas

  • Ophthalmology


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