TY - JOUR
T1 - Micrornas modulate signaling pathways in osteogenic differentiation of mesenchymal stem cells
AU - Mazziotta, Chiara
AU - Lanzillotti, Carmen
AU - Iaquinta, Maria Rosa
AU - Taraballi, Francesca
AU - Torreggiani, Elena
AU - Rotondo, John Charles
AU - Otòn-Gonzalez, Lucia
AU - Mazzoni, Elisa
AU - Frontini, Francesca
AU - Bononi, Ilaria
AU - De Mattei, Monica
AU - Tognon, Mauro
AU - Martini, Fernanda
N1 - Funding Information:
Funding: The work of the authors cited in this review was supported, in part, by the University of Ferrara FAR and FIR grants, Regione Emilia-Romagna POR FESR project “NIPROGEN,” and MIUR PRIN 2017 C8RYSS. University of Ferrara, FAR and FIR grants, Region Emilia-Romagna, FESR POR “NIPROGEN” project and Ministero della Università e della Ricerca, PRIN 2017 project, were the agencies funding this work. These agencies contributed, in part, to the work carried out by the authors. The open access publication fee of this work is paid by the grants.
Publisher Copyright:
© 2021 by the authors. Licensee MDPI, Basel, Switzerland.
PY - 2021/3/1
Y1 - 2021/3/1
N2 - Mesenchymal stem cells (MSCs) have been identified in many adult tissues and they have been closely studied in recent years, especially in view of their potential use for treating diseases and damaged tissues and organs. MSCs are capable of self-replication and differentiation into osteoblasts and are considered an important source of cells in tissue engineering for bone regeneration. Several epigenetic factors are believed to play a role in the osteogenic differentiation of MSCs, including microRNAs (miRNAs). MiRNAs are small, single-stranded, non-coding RNAs of approximately 22 nucleotides that are able to regulate cell proliferation, differentiation and apoptosis by binding the 3′ untranslated region (3′-UTR) of target mRNAs, which can be subsequently degraded or translationally silenced. MiRNAs control gene expression in osteogenic differentiation by regulating two crucial signaling cascades in osteogenesis: the transforming growth factor-beta (TGF-β)/bone morphogenic protein (BMP) and the Wingless/Int-1(Wnt)/β-catenin signaling pathways. This review provides an overview of the miRNAs involved in osteogenic differentiation and how these miRNAs could regulate the expression of target genes.
AB - Mesenchymal stem cells (MSCs) have been identified in many adult tissues and they have been closely studied in recent years, especially in view of their potential use for treating diseases and damaged tissues and organs. MSCs are capable of self-replication and differentiation into osteoblasts and are considered an important source of cells in tissue engineering for bone regeneration. Several epigenetic factors are believed to play a role in the osteogenic differentiation of MSCs, including microRNAs (miRNAs). MiRNAs are small, single-stranded, non-coding RNAs of approximately 22 nucleotides that are able to regulate cell proliferation, differentiation and apoptosis by binding the 3′ untranslated region (3′-UTR) of target mRNAs, which can be subsequently degraded or translationally silenced. MiRNAs control gene expression in osteogenic differentiation by regulating two crucial signaling cascades in osteogenesis: the transforming growth factor-beta (TGF-β)/bone morphogenic protein (BMP) and the Wingless/Int-1(Wnt)/β-catenin signaling pathways. This review provides an overview of the miRNAs involved in osteogenic differentiation and how these miRNAs could regulate the expression of target genes.
KW - Bone
KW - Bone regeneration
KW - Cell differentiation
KW - MSCs
KW - Mesenchymal stem cells
KW - MiRNA
KW - MiRNAome
KW - MicroRNA
KW - Osteogenesis
KW - Osteogenic differentiation
KW - Stem cells
UR - http://www.scopus.com/inward/record.url?scp=85101662561&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85101662561&partnerID=8YFLogxK
U2 - 10.3390/ijms22052362
DO - 10.3390/ijms22052362
M3 - Review article
C2 - 33673409
AN - SCOPUS:85101662561
VL - 22
SP - 1
EP - 21
JO - International journal of molecular sciences
JF - International journal of molecular sciences
SN - 1661-6596
IS - 5
M1 - 2362
ER -