MicroRNAs and other mechanisms regulate interleukin-17 cytokines and receptors

Jietang Mai, Anthony Virtue, Erin Maley, Tran Tran, Ying Yin, Shu Meng, Meghana Pansuria, Xiaohua Jiang, Hong Wang, Xiao Feng Yang

Research output: Contribution to journalArticle

9 Scopus citations

Abstract

Interleukin-17 cytokines are a family of proinflammatory cytokines. Our current studies found: i) IL- 17 cytokines are not ubiquitously expressed, but several receptors and TRAF3IP2 are ubiquitously expressed in tissues with a few exceptions; ii) heart and vascular tissue are in the second tier of readiness to respond to IL-17 cytokine stimulation; iii) alternative transcription starting sites and alternative spliced isoforms are found in IL-17 cytokine and receptor transcripts; iv) higher hypomethylation status is associated with higher expressions of IL-17 receptors; v) the binding sites of several RNA binding proteins are found in the 3'UTRs of the mRNAs of IL-17 cytokines and receptors; and vi) numerous microRNA binding sites are statistically equivalent to that of experimentally verified microRNAsmRNA interactions in the 3'UTRs of IL-17 cytokine and receptor mRNAs. These results suggest that mechanisms including alternative promoters, alternative splicing, RNA binding proteins, and microRNAs regulate the structures and expressions of IL-17 cytokines and receptors. These results provide an insight into the roles of IL-17 in mediating inflammation and immunity.

Original languageEnglish (US)
Pages (from-to)1478-1495
Number of pages18
JournalFrontiers in Bioscience - Elite
Volume4 E
Issue number4
StatePublished - Jan 1 2012

Keywords

  • Gene Expression
  • Interleukin-17 Cytokines
  • Interleukin-17 Receptors
  • MRNA Stability
  • Review
  • Vascular Inflammation

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Immunology and Microbiology(all)

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