MicroRNA Signaling Pathway Network in Pancreatic Ductal Adenocarcinoma

Longhao Sun, Corrine Ying Xuan Chua, Weijun Tian, Zhixiang Zhang, Paul J. Chiao, Wei Zhang

Research output: Contribution to journalReview article

16 Scopus citations

Abstract

Pancreatic ductal adenocarcinoma (PDAC) is considered to be the most lethal and aggressive malignancy with high mortality and poor prognosis. Their responses to current multimodal therapeutic regimens are limited. It is urgently needed to identify the molecular mechanism underlying pancreatic oncogenesis. Twelve core signaling cascades have been established critical in PDAC tumorigenesis by governing a wide variety of cellular processes. MicroRNAs (miRNAs) are aberrantly expressed in different types of tumors and play pivotal roles as post-transcriptional regulators of gene expression. Here, we will describe how miRNAs regulate different signaling pathways that contribute to pancreatic oncogenesis and progression.

Original languageEnglish (US)
Pages (from-to)563-577
Number of pages15
JournalJournal of Genetics and Genomics
Volume42
Issue number10
DOIs
StatePublished - Oct 20 2015

Keywords

  • MicroRNA
  • Pancreatic ductal adenocarcinoma
  • Signaling pathway
  • Tumorigenesis

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics

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