Micronuclei and disease – Report of HUMN project workshop at Rennes 2019 EEMGS conference

Michael Fenech, Nina Holland, Micheline Kirsch-Volders, Lisbeth E. Knudsen, Karl Heinz Wagner, Helga Stopper, Siegfried Knasmueller, Claudia Bolognesi, Randa El-Zein, Stefano Bonassi

Research output: Contribution to journalShort survey

4 Scopus citations

Abstract

The “Micronuclei and Disease” workshop was organized by the HUMN Project consortium and hosted by the European Environmental Mutagen and Genomics Society at their annual meeting in Rennes, France, on 23 May 2019. The program of the workshop focused on addressing the emerging evidence linking micronucleus (MN) frequency to human disease. The first objective was to review what has been published and evaluate the level and quality of evidence for the connection between MN frequency and various diseases through all life stages. The second objective was to identify the knowledge gaps and what else needs to be done to determine the clinical utility of MN assays as predictors of disease risk and of prognosis when disease is active. Speakers at the workshop discussed the association of MN frequency with inflammation, infertility, pregnancy complications, obesity, diabetes, cardiovascular disease, kidney disease, cervical and bladder cancer, oral head and neck cancer, lung cancer, accelerated ageing syndromes, neurodegenerative diseases, and a road-map on how to utilise this knowledge was proposed. The outcomes of the workshop indicated that there are significant opportunities for translating the application of MN assays into clinical practice to improve disease prevention and risk management and to inform public health policy.

Original languageEnglish (US)
Article number503133
JournalMutation Research - Genetic Toxicology and Environmental Mutagenesis
Volume850-851
DOIs
StatePublished - Feb 1 2020

Keywords

  • Disease
  • HUMN
  • Micronuclei
  • Micronucleus
  • Report
  • Workshop

ASJC Scopus subject areas

  • Genetics
  • Health, Toxicology and Mutagenesis

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