Micrographia in parkinson’s disease

J. L. Contreras-Vidal, H. L. Teulings, G. E. Stelmach

Research output: Contribution to journalArticle

35 Scopus citations

Abstract

A computational neural model of movement production in normal and Parkinson's disease (PD) is used to provide a neural account for the source of micrographia in PD handwriting. It is hypothesized that smaller than normal pallido-thalamic signals, due to dopamine depletion, are responsible for the observed overall smallness, slowness and variability in PD handwriting. Experimental data from PD patients that show micrographia support this hypothesis and imply the functional segregation of basal ganglia neural populations.

Original languageEnglish (US)
Pages (from-to)2089-2092
Number of pages4
JournalNeuroReport
Volume6
Issue number15
DOIs
StatePublished - Oct 1995

Keywords

  • Basal ganglia
  • Dopamine
  • Dynamics in Parkinson's disease
  • Handwriting
  • Micrographia
  • Neural network
  • Neurotransmitter
  • Parkinson's disease

ASJC Scopus subject areas

  • Neuroscience(all)

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