Microglial activation, recruitment and phagocytosis as linked phenomena in ferric oxide nanoparticle exposure

Yun Wang, Bing Wang, Mo Tao Zhu, Ming Li, Hua Jian Wang, Meng Wang, Hong Ouyang, Zhi Fang Chai, Wei Yue Feng, Yu Liang Zhao

Research output: Contribution to journalArticle

91 Scopus citations

Abstract

Microglia as the resident macrophage-like cells in the central nervous system (CNS) play a pivotal role in the innate immune responses of CNS. Understanding the reactions of microglia cells to nanoparticle exposure is important in the exploration of neurobiology of nanoparticles. Here we provide a systemic mapping of microglia and the corresponding pathological changes in olfactory-transport related brain areas of mice with Fe2O3-nanoparticle intranasal treatment. We showed that intranasal exposure of Fe2O3 nanoparticle could lead to pathological alteration in olfactory bulb, hippocampus and striatum, and caused microglial proliferation, activation and recruitment in these areas, especially in olfactory bulb. Further experiments with BV2 microglial cells showed the exposure to Fe2O3 nanoparticles could induce cells proliferation, phagocytosis and generation of ROS and NO, but did not cause significant release of inflammatory factors, including IL-1β, IL-6 and TNF-α. Our results indicate that microglial activation may act as an alarm and defense system in the processes of the exogenous nanoparticles invading and storage in brain.

Original languageEnglish (US)
Pages (from-to)26-37
Number of pages12
JournalToxicology Letters
Volume205
Issue number1
DOIs
StatePublished - Aug 10 2011

Keywords

  • Ferric oxide nanoparticles
  • Microglial activation
  • Neurotoxicity

ASJC Scopus subject areas

  • Toxicology

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