Microfluidic-based cell manipulation in viscoelastic fluids

F. Del Giudice, S. Sathish, Amy Q. Shen

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Deformability is a critical parameter for discriminating healthy and diseased cells [1]. Several complex microfluidics devices are currently available for separating cells with different deformabilities. Viscoelastic fluids have also been used for particle/cell separation to simplify the microfluidic design [2]. Channel design strongly depends on both fluid rheology [3] and cell deformability [4]. In this work, we study the effect of cell deformability on particle/cell migration perpendicular to the flow, using particles/cells with similar sizes, but different deformabilities, suspended in 2 different viscoelastic fluids, in a straight 150 μm square-shaped microchannel.

Original languageEnglish (US)
Title of host publication20th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2016
PublisherChemical and Biological Microsystems Society
Pages838-839
Number of pages2
ISBN (Electronic)9780979806490
StatePublished - 2016
Event20th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2016 - Dublin, Ireland
Duration: Oct 9 2016Oct 13 2016

Other

Other20th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2016
CountryIreland
CityDublin
Period10/9/1610/13/16

Keywords

  • Cell migration
  • Deformability
  • Focusing
  • Viscoelastic

ASJC Scopus subject areas

  • Control and Systems Engineering

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