Microfluidic assembly of liposomes with tunable size and coloading capabilities

Jessica R. Hoffman, Ennio Tasciotti, Roberto Molinaro

Research output: Chapter in Book/Report/Conference proceedingChapter

4 Scopus citations

Abstract

Liposomes used for the delivery of pharmaceuticals have difficulties scaling up and reaching clinical translation as they suffer from batch-to-batch variability. Here, we describe a microfluidic approach for creating reproducible, homogenous nanoparticles with tunable characteristics. These nanoparticles of sizes ranging from 30 to 500 nm are rapidly self-assembled by controlling the flow rates of ethanol and aqueous streams. This method of microfluidic assembly allows for the efficient encapsulation of both hydrophobic and hydrophilic drugs in the lipid bilayer and particle core, respectively, either separately or in combination.

Original languageEnglish (US)
Title of host publicationMethods in Molecular Biology
PublisherHumana Press
Pages205-214
Number of pages10
DOIs
StatePublished - 2018

Publication series

NameMethods in Molecular Biology
Volume1792
ISSN (Print)1064-3745

Keywords

  • Coloading
  • Liposomes
  • Microfluidics
  • Nanomedicine
  • Reproducibility
  • Scale up

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics

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