Microfabricated membranes for immunoisolation

D. Hansford, T. Desai, M. Ferrari

Research output: Chapter in Book/Report/Conference proceedingConference contribution

1 Scopus citations

Abstract

The application of microfabrication technology to create precise separation and isolation membranes for biomedical applications is reviewed. By utilizing standard microfabrication techniques, membranes were fabricated with well-controlled and uniform pore sizes, allowing the optimization of membrane parameters for cell immunoisolation. The membrane forming process employs bulk and surface micromachining to define chambers within single crystalline silicon wafers that interface with the surrounding biological environment through polycrystalline silicon filter membranes. Membranes were fabricated to present a high density of uniform pores to allow sufficient permeability to nutrients while preventing the passage of immunoglobulin G. The semipermeability of microfabricated membranes, their biocompatibility, ease in sterilization, along with their thermal and chemical stability, may provide significant advantages for biomedical applications.

Original languageEnglish (US)
Title of host publicationAnnual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings
PublisherInstitute of Electrical and Electronics Engineers Inc.
Number of pages1
Volume2
ISBN (Print)0780356756
StatePublished - Dec 1 1999
EventProceedings of the 1999 IEEE Engineering in Medicine and Biology 21st Annual Conference and the 1999 Fall Meeting of the Biomedical Engineering Society (1st Joint BMES / EMBS) - Atlanta, GA, USA
Duration: Oct 13 1999Oct 16 1999

Other

OtherProceedings of the 1999 IEEE Engineering in Medicine and Biology 21st Annual Conference and the 1999 Fall Meeting of the Biomedical Engineering Society (1st Joint BMES / EMBS)
CityAtlanta, GA, USA
Period10/13/9910/16/99

ASJC Scopus subject areas

  • Signal Processing
  • Biomedical Engineering
  • Computer Vision and Pattern Recognition
  • Health Informatics

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