Microfabricated biocapsules for cell xenografts: A review

Tejal A. Desai, Wen Hwa Chu, Jay K. Tu, Polly Shrewsbury, Mauro Ferrari

Research output: Contribution to journalConference article

13 Scopus citations

Abstract

Immune rejection rapidly destroys cellular transplants, particularly xenografts. Encapsulation of xenografts with an artificial membrane has been proposed as a means of cell immunoprotection after transplantation. Currently, organic biocapsule materials are used in this context, and have presented significant problems that relate to capsule biodegradation and limited biocompatibility. In this review, we describe our alternative approach to immunoisolation using microfabricated biocapsules. Previous studies have shown the viability and functionality of various cell lines within our biocapsule microfabricated environment. This review describes general cell culture wafer and biocapsule fabrication protocols, as well as, in vitro studies on the viability and functionality of pancreatic islets of Langerhans in microfabricated culture wafers and biocapsules.

Original languageEnglish (US)
Pages (from-to)216-226
Number of pages11
JournalProceedings of SPIE - The International Society for Optical Engineering
Volume2978
DOIs
StatePublished - Dec 1 1997
EventMicro- and Nanofabricated Electro-Optical Mechanical Systems for Biomedical and Environmental Applications - San Jose, CA, United States
Duration: Feb 10 1997Feb 10 1997

Keywords

  • BioMEMS
  • Biocompatibility
  • Biohybrid organs
  • Islets of Langerhans
  • Microfabricated
  • Silicon

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Condensed Matter Physics
  • Computer Science Applications
  • Applied Mathematics
  • Electrical and Electronic Engineering

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