Microcirculatory Alterations in Shock States

Shannan K. Hamlin, C. Lee Parmley, Sandra K. Hanneman

Research output: Contribution to journalReview articlepeer-review

6 Scopus citations


Functional components of the microcirculation provide oxygen and nutrients and remove waste products from the tissue beds of the body's organs. Shock states overwhelmingly stress functional capacity of the microcirculation, resulting in microcirculatory failure. In septic shock, inflammatory mediators contribute to hemodynamic instability. In nonseptic shock states, the microcirculation is better able to compensate for alterations in vascular resistance, cardiac output, and blood pressure. Therefore, global hemodynamic and oxygen delivery parameters are appropriate for assessing, monitoring, and guiding therapy in hypovolemic and cardiogenic shock but, alone, are inadequate for septic shock.

Original languageEnglish (US)
Pages (from-to)399-412
Number of pages14
JournalCritical Care Nursing Clinics of North America
Issue number3
StatePublished - Jan 1 2014


  • Blood flow
  • Cardiogenic shock
  • Hypovolemic shock
  • Microcirculation
  • Oxygen extraction
  • Oxygen transport
  • Oxygen utilization
  • Septic shock

ASJC Scopus subject areas

  • Critical Care


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