Microbial adhesins recognizing extracellular matrix macromolecules

Joseph M. Patti, Magnus Höök

Research output: Contribution to journalArticle

189 Scopus citations

Abstract

Microorganisms express a family of cell-surface adhesins that specifically recognize and bind components of the extracellular matrix. Adhesion of microorganisms to host tissues represents a critical phase in the development of many types of infections. Recent studies have focused on the mechanisms of microbial attachment at a molecular level, including the identification of ligand-binding domains in several cell-surface adhesins from Gram-positive bacteria and the construction of adhesin-deficient isogenic mutants.

Original languageEnglish (US)
Pages (from-to)752-758
Number of pages7
JournalCurrent Opinion in Cell Biology
Volume6
Issue number5
DOIs
StatePublished - Oct 1994

ASJC Scopus subject areas

  • Cell Biology

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