Micro-retroreflectors in immunoassays and biosensors

S. M. Kemper, T. Sherlock, J. D. Knoop, E. Cacao, P. Ruchhoeft, R. L. Atmar, Richard C. Willson

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Many current bioanalytical and diagnostic methods rely on labeling the species of interest and the use of specialized detection equipment to monitor the label. Incorporation of retroreflectors into immunoassays and biosensors offers a novel and economical solution to problems associated with these methods and provides a detection assay useful in clinical and defense applications. Spotting of various detection antibodies on various test surfaces was done to test the viability of a "syndrome chip" for use in clinical diagnostics. Magnetic particles were used to incorporate magnetic stringency into the assay, which when combined with microfluidics will increase the specificity of the system. Such a chip would be activated with capture antibodies for several common disease vectors as well as some that are less common and may have bioterrorism applications.

Original languageEnglish (US)
Title of host publicationTechnical Proceedings of the 2008 NSTI Nanotechnology Conference and Trade Show, NSTI-Nanotech, Nanotechnology 2008
Pages585-588
Number of pages4
Volume2
StatePublished - Oct 1 2008
Event2008 NSTI Nanotechnology Conference and Trade Show, NSTI Nanotech 2008 Joint Meeting, Nanotechnology 2008 - Quebec City, QC, United States
Duration: Jun 1 2008Jun 5 2008

Other

Other2008 NSTI Nanotechnology Conference and Trade Show, NSTI Nanotech 2008 Joint Meeting, Nanotechnology 2008
CountryUnited States
CityQuebec City, QC
Period6/1/086/5/08

Keywords

  • Bioassay
  • Biosensor
  • Diagnostics
  • Immunoassay
  • Retroreflectors

ASJC Scopus subject areas

  • Mechanical Engineering

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