Micro- and nanoscale devices for the investigation of epigenetics and chromatin dynamics

Carlos A. Aguilar, Harold G. Craighead

Research output: Contribution to journalReview article

38 Scopus citations

Abstract

Deoxyribonucleic acid (DNA) is the blueprint on which life is based and transmitted, but the way in which chromatin-a dynamic complex of nucleic acids and proteins-is packaged and behaves in the cellular nucleus has only begun to be investigated. Epigenetic modifications sit 'on top of' the genome and affect how DNA is compacted into chromatin and transcribed into ribonucleic acid (RNA). The packaging and modifications around the genome have been shown to exert significant influence on cellular behaviour and, in turn, human development and disease. However, conventional techniques for studying epigenetic or conformational modifications of chromosomes have inherent limitations and, therefore, new methods based on micro- and nanoscale devices have been sought. Here, we review the development of these devices and explore their use in the study of DNA modifications, chromatin modifications and higher-order chromatin structures.

Original languageEnglish (US)
Pages (from-to)709-718
Number of pages10
JournalNature Nanotechnology
Volume8
Issue number10
DOIs
StatePublished - Oct 2013

ASJC Scopus subject areas

  • Bioengineering
  • Atomic and Molecular Physics, and Optics
  • Biomedical Engineering
  • Materials Science(all)
  • Condensed Matter Physics
  • Electrical and Electronic Engineering

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