MGMT: A personal perspective

Sankar Mitra

doi:10.1016/j.dnarep.2007.03.007

MGMT: A personal perspective

Sankar Mitra

Research output: Contribution to journal › Article › peer-review

46 Scopus citations

Abstract

This review describes the history of studies on alkylation damage of mammalian genomes and its carcinogenic consequences that led to the discovery of a unique DNA repair protein, named MGMT. MGMT repairs O⁶-alkylguanine, a critical mutagenic lesion induced by alkylating agents. The follow-up studies in mammalian cells following the discovery of the ubiquitous repair protein in E. coli are summarized.

Original language	English (US)
Pages (from-to)	1064-1070
Number of pages	7
Journal	DNA Repair
Volume	6
Issue number	8
DOIs	https://doi.org/10.1016/j.dnarep.2007.03.007
State	Published - Aug 1 2007

Keywords

Adaptive response in E. coli
Alkylation damage repair and mutagenesis
Drug resistance

ASJC Scopus subject areas

Biochemistry
Molecular Biology

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10.1016/j.dnarep.2007.03.007

Cite this

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title = "MGMT: A personal perspective",

abstract = "This review describes the history of studies on alkylation damage of mammalian genomes and its carcinogenic consequences that led to the discovery of a unique DNA repair protein, named MGMT. MGMT repairs O6-alkylguanine, a critical mutagenic lesion induced by alkylating agents. The follow-up studies in mammalian cells following the discovery of the ubiquitous repair protein in E. coli are summarized.",

keywords = "Adaptive response in E. coli, Alkylation damage repair and mutagenesis, Drug resistance",

author = "Sankar Mitra",

note = "Funding Information: The MGMT studies in my laboratory were initiated in 1978 in collaboration with Bimal C. Pal and Robert S. Foote who are organic chemists. These evolved into investigations in areas of cell biology, which were far beyond the range of my own expertise. This progression of scientific endeavor could not have been possible without collaboration of so many other colleagues including Warren Masker, Tony Pegg, Rufus Day, Dan Yarosh, Bernd Kaina, Tom Brent, Mituo Ikenaga and many talented postdocs and students in my own lab. My research efforts were supported by USPHS grants R01 CA31721, R01 ES07572 and R01 CA53791.",

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doi = "10.1016/j.dnarep.2007.03.007",

language = "English (US)",

volume = "6",

pages = "1064--1070",

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N2 - This review describes the history of studies on alkylation damage of mammalian genomes and its carcinogenic consequences that led to the discovery of a unique DNA repair protein, named MGMT. MGMT repairs O6-alkylguanine, a critical mutagenic lesion induced by alkylating agents. The follow-up studies in mammalian cells following the discovery of the ubiquitous repair protein in E. coli are summarized.

AB - This review describes the history of studies on alkylation damage of mammalian genomes and its carcinogenic consequences that led to the discovery of a unique DNA repair protein, named MGMT. MGMT repairs O6-alkylguanine, a critical mutagenic lesion induced by alkylating agents. The follow-up studies in mammalian cells following the discovery of the ubiquitous repair protein in E. coli are summarized.

KW - Adaptive response in E. coli

KW - Alkylation damage repair and mutagenesis

KW - Drug resistance

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JO - DNA Repair

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IS - 8

ER -

MGMT: A personal perspective

Abstract

Keywords

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