TY - JOUR
T1 - MGMT
T2 - A personal perspective
AU - Mitra, Sankar
N1 - Funding Information:
The MGMT studies in my laboratory were initiated in 1978 in collaboration with Bimal C. Pal and Robert S. Foote who are organic chemists. These evolved into investigations in areas of cell biology, which were far beyond the range of my own expertise. This progression of scientific endeavor could not have been possible without collaboration of so many other colleagues including Warren Masker, Tony Pegg, Rufus Day, Dan Yarosh, Bernd Kaina, Tom Brent, Mituo Ikenaga and many talented postdocs and students in my own lab. My research efforts were supported by USPHS grants R01 CA31721, R01 ES07572 and R01 CA53791.
Copyright:
Copyright 2009 Elsevier B.V., All rights reserved.
PY - 2007/8/1
Y1 - 2007/8/1
N2 - This review describes the history of studies on alkylation damage of mammalian genomes and its carcinogenic consequences that led to the discovery of a unique DNA repair protein, named MGMT. MGMT repairs O6-alkylguanine, a critical mutagenic lesion induced by alkylating agents. The follow-up studies in mammalian cells following the discovery of the ubiquitous repair protein in E. coli are summarized.
AB - This review describes the history of studies on alkylation damage of mammalian genomes and its carcinogenic consequences that led to the discovery of a unique DNA repair protein, named MGMT. MGMT repairs O6-alkylguanine, a critical mutagenic lesion induced by alkylating agents. The follow-up studies in mammalian cells following the discovery of the ubiquitous repair protein in E. coli are summarized.
KW - Adaptive response in E. coli
KW - Alkylation damage repair and mutagenesis
KW - Drug resistance
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U2 - 10.1016/j.dnarep.2007.03.007
DO - 10.1016/j.dnarep.2007.03.007
M3 - Article
C2 - 17482889
AN - SCOPUS:34447314166
VL - 6
SP - 1064
EP - 1070
JO - DNA Repair
JF - DNA Repair
SN - 1568-7864
IS - 8
ER -