MGMT: A personal perspective

Research output: Contribution to journalArticle

37 Scopus citations

Abstract

This review describes the history of studies on alkylation damage of mammalian genomes and its carcinogenic consequences that led to the discovery of a unique DNA repair protein, named MGMT. MGMT repairs O6-alkylguanine, a critical mutagenic lesion induced by alkylating agents. The follow-up studies in mammalian cells following the discovery of the ubiquitous repair protein in E. coli are summarized.

Original languageEnglish (US)
Pages (from-to)1064-1070
Number of pages7
JournalDNA Repair
Volume6
Issue number8
DOIs
StatePublished - Aug 1 2007

Keywords

  • Adaptive response in E. coli
  • Alkylation damage repair and mutagenesis
  • Drug resistance

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology

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