MGMT: A personal perspective

Sankar Mitra

doi:10.1016/j.dnarep.2007.03.007

MGMT: A personal perspective

Sankar Mitra

Research output: Contribution to journal › Article

37 Scopus citations

Abstract

This review describes the history of studies on alkylation damage of mammalian genomes and its carcinogenic consequences that led to the discovery of a unique DNA repair protein, named MGMT. MGMT repairs O⁶-alkylguanine, a critical mutagenic lesion induced by alkylating agents. The follow-up studies in mammalian cells following the discovery of the ubiquitous repair protein in E. coli are summarized.

Original language	English (US)
Pages (from-to)	1064-1070
Number of pages	7
Journal	DNA Repair
Volume	6
Issue number	8
DOIs	https://doi.org/10.1016/j.dnarep.2007.03.007
State	Published - Aug 1 2007

Keywords

Adaptive response in E. coli
Alkylation damage repair and mutagenesis
Drug resistance

ASJC Scopus subject areas

Biochemistry
Molecular Biology

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10.1016/j.dnarep.2007.03.007

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abstract = "This review describes the history of studies on alkylation damage of mammalian genomes and its carcinogenic consequences that led to the discovery of a unique DNA repair protein, named MGMT. MGMT repairs O6-alkylguanine, a critical mutagenic lesion induced by alkylating agents. The follow-up studies in mammalian cells following the discovery of the ubiquitous repair protein in E. coli are summarized.",

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