Methylarginines in Mice with Experimental Atherosclerosis

M. A. Gilinsky; R. A. Sukhovershin; M. S. Cherkanova

doi:10.1007/s10517-015-3086-3

Methylarginines in Mice with Experimental Atherosclerosis

M. A. Gilinsky, R. A. Sukhovershin, M. S. Cherkanova

Houston Methodist

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

Abstract

We studied the dynamics of indexes for the system of endogenous regulation of NO bioavailability. The content of NO synthase inhibitors (monomethylarginine and asymmetric dimethylarginine) in the blood of mice was measured after intraperitoneal injections of a nonionic surfactant poloxamer 407 for 2 and 14 weeks. The concentrations of both methylarginines in animals with atherosclerosis due to 14-week administration of poloxamer were much higher than in control specimens. The amount of arginine and symmetric dimethylarginine practically did not differ from the control. Poloxamer-induced model of atherosclerosis is characterized by increased content of NO synthase inhibitors. These changes contribute to the development of endothelial dysfunction and atherosclerosis.

Original language	English (US)
Pages (from-to)	13-16
Number of pages	4
Journal	Bulletin of Experimental Biology and Medicine
Volume	160
Issue number	1
DOIs	https://doi.org/10.1007/s10517-015-3086-3
State	Published - Nov 1 2015

Keywords

asymmetric dimethylarginine
athero-sclerosis
monomethylarginine
poloxamer 407

ASJC Scopus subject areas

Biochemistry, Genetics and Molecular Biology(all)

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10.1007/s10517-015-3086-3

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title = "Methylarginines in Mice with Experimental Atherosclerosis",

abstract = "We studied the dynamics of indexes for the system of endogenous regulation of NO bioavailability. The content of NO synthase inhibitors (monomethylarginine and asymmetric dimethylarginine) in the blood of mice was measured after intraperitoneal injections of a nonionic surfactant poloxamer 407 for 2 and 14 weeks. The concentrations of both methylarginines in animals with atherosclerosis due to 14-week administration of poloxamer were much higher than in control specimens. The amount of arginine and symmetric dimethylarginine practically did not differ from the control. Poloxamer-induced model of atherosclerosis is characterized by increased content of NO synthase inhibitors. These changes contribute to the development of endothelial dysfunction and atherosclerosis.",

keywords = "asymmetric dimethylarginine, athero-sclerosis, monomethylarginine, poloxamer 407",

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note = "Funding Information: This work was supported by the Russian Foundation for Basic Research (grant No. 13-04-01079). Publisher Copyright: {\textcopyright} 2015, Springer Science+Business Media New York. Copyright: Copyright 2016 Elsevier B.V., All rights reserved.",

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AU - Cherkanova, M. S.

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Methylarginines in Mice with Experimental Atherosclerosis

Abstract

Keywords

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