Methyladenosine Modification in RNAs: From Regulatory Roles to Therapeutic Implications in Cancer

Xiaolin Qu, Yongqiu Zhang, Xianzheng Sang, Ding Ren, Hong Zhao, Stephen T.C. Wong

Research output: Contribution to journalReview articlepeer-review

1 Scopus citations

Abstract

Methyladenosine modifications are the most abundant RNA modifications, including N6-methyladenosine (m6A), N1-methyladenosine (m1A), and 2’-O-methyladenosine (m6Am). As reversible epigenetic modifications, methyladenosine modifications in eukaryotic RNAs are not invariable. Drastic alterations of m6A are found in a variety of diseases, including cancers. Dynamic changes of m6A modification induced by abnormal methyltransferase, demethylases, and readers can regulate cancer progression via interfering with the splicing, localization, translation, and stability of mRNAs. Meanwhile, m6A, m1A, and m6Am modifications also exert regulatory effects on noncoding RNAs in cancer progression. In this paper, we reviewed recent findings concerning the underlying biomechanism of methyladenosine modifications in oncogenesis and metastasis and discussed the therapeutic potential of methyladenosine modifications in cancer treatments.

Original languageEnglish (US)
Article number3195
JournalCancers
Volume14
Issue number13
DOIs
StatePublished - Jul 1 2022

Keywords

  • cancer
  • m6A
  • methyladenosine
  • oncogenesis
  • therapy

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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