Methods of Prospective Investigation of Pulmonary Embolism Diagnosis III (PIOPED III)

Paul D. Stein; Alexander Gottschalk; Henry Dirk Sostman; Thomas L. Chenevert; Sarah E. Fowler; Lawrence R. Goodman; Charles A. Hales; Russell D. Hull; Emanuel Kanal; Kenneth V. Leeper; David P. Nadich; Daniel J. Sak; Victor F. Tapson; Thomas W. Wakefield; John G. Weg; Pamela K. Woodard

doi:10.1053/j.semnuclmed.2008.06.003

Methods of Prospective Investigation of Pulmonary Embolism Diagnosis III (PIOPED III)

Paul D. Stein, Alexander Gottschalk, Henry Dirk Sostman, Thomas L. Chenevert, Sarah E. Fowler, Lawrence R. Goodman, Charles A. Hales, Russell D. Hull, Emanuel Kanal, Kenneth V. Leeper, David P. Nadich, Daniel J. Sak, Victor F. Tapson, Thomas W. Wakefield, John G. Weg, Pamela K. Woodard

Research output: Contribution to journal › Article › peer-review

48 Scopus citations

Abstract

In this work, the methods of the Prospective Investigation of Pulmonary Embolism Diagnosis III (PIOPED III) are described in detail. PIOPED III is a multicenter collaborative investigation sponsored by the National Heart, Lung and Blood Institute. The purpose is to determine the accuracy of gadolinium-enhanced magnetic resonance angiography in combination with venous phase magnetic resonance venography for the diagnosis of acute pulmonary embolism (PE). A composite reference standard based on usual diagnostic methods for PE is used. All images will be read by 2 blinded and study-certified central readers. Patients with no PE according to the composite reference test will be randomized to undergo gadolinium-enhanced magnetic resonance angiography in combination with venous phase magnetic resonance venography. This procedure will reduce the proportion of patients with negative tests at no loss in evaluation of sensitivity and specificity.

Original language	English (US)
Pages (from-to)	462-470
Number of pages	9
Journal	Seminars in Nuclear Medicine
Volume	38
Issue number	6
DOIs	https://doi.org/10.1053/j.semnuclmed.2008.06.003
State	Published - Nov 2008

ASJC Scopus subject areas

Radiology Nuclear Medicine and imaging

Access to Document

10.1053/j.semnuclmed.2008.06.003

Cite this

Stein, P. D., Gottschalk, A., Sostman, H. D., Chenevert, T. L., Fowler, S. E., Goodman, L. R., Hales, C. A., Hull, R. D., Kanal, E., Leeper, K. V., Nadich, D. P., Sak, D. J., Tapson, V. F., Wakefield, T. W., Weg, J. G., & Woodard, P. K. (2008). Methods of Prospective Investigation of Pulmonary Embolism Diagnosis III (PIOPED III). Seminars in Nuclear Medicine, 38(6), 462-470. https://doi.org/10.1053/j.semnuclmed.2008.06.003

Stein, PD, Gottschalk, A, Sostman, HD, Chenevert, TL, Fowler, SE, Goodman, LR, Hales, CA, Hull, RD, Kanal, E, Leeper, KV, Nadich, DP, Sak, DJ, Tapson, VF, Wakefield, TW, Weg, JG & Woodard, PK 2008, 'Methods of Prospective Investigation of Pulmonary Embolism Diagnosis III (PIOPED III)', Seminars in Nuclear Medicine, vol. 38, no. 6, pp. 462-470. https://doi.org/10.1053/j.semnuclmed.2008.06.003

@article{b65b1afd5f6840a186a7fd47cfbda081,

title = "Methods of Prospective Investigation of Pulmonary Embolism Diagnosis III (PIOPED III)",

abstract = "In this work, the methods of the Prospective Investigation of Pulmonary Embolism Diagnosis III (PIOPED III) are described in detail. PIOPED III is a multicenter collaborative investigation sponsored by the National Heart, Lung and Blood Institute. The purpose is to determine the accuracy of gadolinium-enhanced magnetic resonance angiography in combination with venous phase magnetic resonance venography for the diagnosis of acute pulmonary embolism (PE). A composite reference standard based on usual diagnostic methods for PE is used. All images will be read by 2 blinded and study-certified central readers. Patients with no PE according to the composite reference test will be randomized to undergo gadolinium-enhanced magnetic resonance angiography in combination with venous phase magnetic resonance venography. This procedure will reduce the proportion of patients with negative tests at no loss in evaluation of sensitivity and specificity.",

author = "Stein, {Paul D.} and Alexander Gottschalk and Sostman, {Henry Dirk} and Chenevert, {Thomas L.} and Fowler, {Sarah E.} and Goodman, {Lawrence R.} and Hales, {Charles A.} and Hull, {Russell D.} and Emanuel Kanal and Leeper, {Kenneth V.} and Nadich, {David P.} and Sak, {Daniel J.} and Tapson, {Victor F.} and Wakefield, {Thomas W.} and Weg, {John G.} and Woodard, {Pamela K.}",

note = "Funding Information: Supported by grants from the U.S. Department of Health and Human Services, Public Health Services, National Heart, Lung, and Blood Institute, Bethesda, Maryland: HL081593, HL177150, HL077149, HL077151, HL077154, HL081594, HL077358, HL077155, and HL077153. ",

year = "2008",

month = nov,

doi = "10.1053/j.semnuclmed.2008.06.003",

language = "English (US)",

volume = "38",

pages = "462--470",

journal = "Seminars in Nuclear Medicine",

issn = "0001-2998",

publisher = "W.B. Saunders Ltd",

number = "6",

}

TY - JOUR

T1 - Methods of Prospective Investigation of Pulmonary Embolism Diagnosis III (PIOPED III)

AU - Stein, Paul D.

AU - Gottschalk, Alexander

AU - Sostman, Henry Dirk

AU - Chenevert, Thomas L.

AU - Fowler, Sarah E.

AU - Goodman, Lawrence R.

AU - Hales, Charles A.

AU - Hull, Russell D.

AU - Kanal, Emanuel

AU - Leeper, Kenneth V.

AU - Nadich, David P.

AU - Sak, Daniel J.

AU - Tapson, Victor F.

AU - Wakefield, Thomas W.

AU - Weg, John G.

AU - Woodard, Pamela K.

N1 - Funding Information: Supported by grants from the U.S. Department of Health and Human Services, Public Health Services, National Heart, Lung, and Blood Institute, Bethesda, Maryland: HL081593, HL177150, HL077149, HL077151, HL077154, HL081594, HL077358, HL077155, and HL077153.

PY - 2008/11

Y1 - 2008/11

N2 - In this work, the methods of the Prospective Investigation of Pulmonary Embolism Diagnosis III (PIOPED III) are described in detail. PIOPED III is a multicenter collaborative investigation sponsored by the National Heart, Lung and Blood Institute. The purpose is to determine the accuracy of gadolinium-enhanced magnetic resonance angiography in combination with venous phase magnetic resonance venography for the diagnosis of acute pulmonary embolism (PE). A composite reference standard based on usual diagnostic methods for PE is used. All images will be read by 2 blinded and study-certified central readers. Patients with no PE according to the composite reference test will be randomized to undergo gadolinium-enhanced magnetic resonance angiography in combination with venous phase magnetic resonance venography. This procedure will reduce the proportion of patients with negative tests at no loss in evaluation of sensitivity and specificity.

AB - In this work, the methods of the Prospective Investigation of Pulmonary Embolism Diagnosis III (PIOPED III) are described in detail. PIOPED III is a multicenter collaborative investigation sponsored by the National Heart, Lung and Blood Institute. The purpose is to determine the accuracy of gadolinium-enhanced magnetic resonance angiography in combination with venous phase magnetic resonance venography for the diagnosis of acute pulmonary embolism (PE). A composite reference standard based on usual diagnostic methods for PE is used. All images will be read by 2 blinded and study-certified central readers. Patients with no PE according to the composite reference test will be randomized to undergo gadolinium-enhanced magnetic resonance angiography in combination with venous phase magnetic resonance venography. This procedure will reduce the proportion of patients with negative tests at no loss in evaluation of sensitivity and specificity.

UR - http://www.scopus.com/inward/record.url?scp=53149100139&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=53149100139&partnerID=8YFLogxK

U2 - 10.1053/j.semnuclmed.2008.06.003

DO - 10.1053/j.semnuclmed.2008.06.003

M3 - Article

C2 - 19331840

AN - SCOPUS:53149100139

SN - 0001-2998

VL - 38

SP - 462

EP - 470

JO - Seminars in Nuclear Medicine

JF - Seminars in Nuclear Medicine

IS - 6

ER -

Methods of Prospective Investigation of Pulmonary Embolism Diagnosis III (PIOPED III)

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this