Metastatic tumor cells – genotypes and phenotypes

Research output: Contribution to journalArticle

Dingcheng Gao, Vivek Mittal, Yi Ban, Ana Rita Lourenco, Shira Yomtoubian, Sharrell Lee

Background: Metastasis is the primary cause of mortality in cancer patients. Therefore, elucidating the genetics and epigenetics of metastatic tumor cells and the mechanisms by which tumor cells acquire metastatic properties constitute significant challenges in cancer research. Objective: To summarize the current understandings of the specific genotype and phenotype of the metastatic tumor cells. Method and Result: In-depth genetic analysis of tumor cells, especially with advances in the next-generation sequencing, have revealed insights of the genotypes of metastatic tumor cells. Also, studies have shown that the cancer stem cell (CSC) and epithelial to mesenchymal transition (EMT) phenotypes are associated with the metastatic cascade. Conclusion: In this review, we will discuss recent advances in the field by focusing on the genomic instability and phenotypic dynamics of metastatic tumor cells.

Original languageEnglish (US)
JournalFrontiers in Biology
DOIs
StateAccepted/In press - 2018

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Metastatic tumor cells – genotypes and phenotypes. / Gao, Dingcheng; Mittal, Vivek; Ban, Yi; Lourenco, Ana Rita; Yomtoubian, Shira; Lee, Sharrell.

In: Frontiers in Biology, 2018.

Research output: Contribution to journalArticle

Harvard

Gao, D, Mittal, V, Ban, Y, Lourenco, AR, Yomtoubian, S & Lee, S 2018, 'Metastatic tumor cells – genotypes and phenotypes' Frontiers in Biology. https://doi.org/10.1007/s11515-018-1513-3

APA

Gao, D., Mittal, V., Ban, Y., Lourenco, A. R., Yomtoubian, S., & Lee, S. (Accepted/In press). Metastatic tumor cells – genotypes and phenotypes. Frontiers in Biology. https://doi.org/10.1007/s11515-018-1513-3

Vancouver

Gao D, Mittal V, Ban Y, Lourenco AR, Yomtoubian S, Lee S. Metastatic tumor cells – genotypes and phenotypes. Frontiers in Biology. 2018. https://doi.org/10.1007/s11515-018-1513-3

Author

Gao, Dingcheng ; Mittal, Vivek ; Ban, Yi ; Lourenco, Ana Rita ; Yomtoubian, Shira ; Lee, Sharrell. / Metastatic tumor cells – genotypes and phenotypes. In: Frontiers in Biology. 2018.

BibTeX

@article{1e72788af9c84ce8961ac6d40911d447,
title = "Metastatic tumor cells – genotypes and phenotypes",
abstract = "Background: Metastasis is the primary cause of mortality in cancer patients. Therefore, elucidating the genetics and epigenetics of metastatic tumor cells and the mechanisms by which tumor cells acquire metastatic properties constitute significant challenges in cancer research. Objective: To summarize the current understandings of the specific genotype and phenotype of the metastatic tumor cells. Method and Result: In-depth genetic analysis of tumor cells, especially with advances in the next-generation sequencing, have revealed insights of the genotypes of metastatic tumor cells. Also, studies have shown that the cancer stem cell (CSC) and epithelial to mesenchymal transition (EMT) phenotypes are associated with the metastatic cascade. Conclusion: In this review, we will discuss recent advances in the field by focusing on the genomic instability and phenotypic dynamics of metastatic tumor cells.",
keywords = "cancer stem cell, cellular plasticity, circulating tumor cells, epithelial to mesenchymal transition (EMT), metastasis, phenotype dynamics Background",
author = "Dingcheng Gao and Vivek Mittal and Yi Ban and Lourenco, {Ana Rita} and Shira Yomtoubian and Sharrell Lee",
year = "2018",
doi = "10.1007/s11515-018-1513-3",
language = "English (US)",
journal = "Frontiers in Biology",
issn = "1674-7984",

}

RIS

TY - JOUR

T1 - Metastatic tumor cells – genotypes and phenotypes

AU - Gao, Dingcheng

AU - Mittal, Vivek

AU - Ban, Yi

AU - Lourenco, Ana Rita

AU - Yomtoubian, Shira

AU - Lee, Sharrell

PY - 2018

Y1 - 2018

N2 - Background: Metastasis is the primary cause of mortality in cancer patients. Therefore, elucidating the genetics and epigenetics of metastatic tumor cells and the mechanisms by which tumor cells acquire metastatic properties constitute significant challenges in cancer research. Objective: To summarize the current understandings of the specific genotype and phenotype of the metastatic tumor cells. Method and Result: In-depth genetic analysis of tumor cells, especially with advances in the next-generation sequencing, have revealed insights of the genotypes of metastatic tumor cells. Also, studies have shown that the cancer stem cell (CSC) and epithelial to mesenchymal transition (EMT) phenotypes are associated with the metastatic cascade. Conclusion: In this review, we will discuss recent advances in the field by focusing on the genomic instability and phenotypic dynamics of metastatic tumor cells.

AB - Background: Metastasis is the primary cause of mortality in cancer patients. Therefore, elucidating the genetics and epigenetics of metastatic tumor cells and the mechanisms by which tumor cells acquire metastatic properties constitute significant challenges in cancer research. Objective: To summarize the current understandings of the specific genotype and phenotype of the metastatic tumor cells. Method and Result: In-depth genetic analysis of tumor cells, especially with advances in the next-generation sequencing, have revealed insights of the genotypes of metastatic tumor cells. Also, studies have shown that the cancer stem cell (CSC) and epithelial to mesenchymal transition (EMT) phenotypes are associated with the metastatic cascade. Conclusion: In this review, we will discuss recent advances in the field by focusing on the genomic instability and phenotypic dynamics of metastatic tumor cells.

KW - cancer stem cell

KW - cellular plasticity

KW - circulating tumor cells

KW - epithelial to mesenchymal transition (EMT)

KW - metastasis

KW - phenotype dynamics Background

UR - http://www.scopus.com/inward/record.url?scp=85051794111&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85051794111&partnerID=8YFLogxK

U2 - 10.1007/s11515-018-1513-3

DO - 10.1007/s11515-018-1513-3

M3 - Article

JO - Frontiers in Biology

T2 - Frontiers in Biology

JF - Frontiers in Biology

SN - 1674-7984

ER -

ID: 40374425