TY - JOUR
T1 - Metal–Organic Framework as a New Type of Magnetothermally-Triggered On-Demand Release Carrier
AU - Ge, Xueying
AU - Mohapatra, Jeotikanta
AU - Silva, Enya
AU - He, Guihua
AU - Gong, Lingshan
AU - Lyu, Tengteng
AU - Madhogaria, Richa P.
AU - Zhao, Xin
AU - Cheng, Yuchuan
AU - Al-Enizi, Abdullah M.
AU - Nafady, Ayman
AU - Tian, Jian
AU - Liu, J. Ping
AU - Phan, Manh Huong
AU - Taraballi, Francesca
AU - Pettigrew, Roderic I.
AU - Ma, Shengqian
N1 - Publisher Copyright:
© 2023 Wiley-VCH GmbH.
PY - 2024/3/22
Y1 - 2024/3/22
N2 - The development of external stimuli-controlled payload systems has been sought after with increasing interest toward magnetothermally-triggered drug release (MTDR) carriers due to their non-invasive features. However, current MTDR carriers present several limitations, such as poor heating efficiency caused by the aggregation of iron oxide nanoparticles (IONPs) or the presence of antiferromagnetic phases which affect their efficiency. Herein, a novel MTDR carrier is developed using a controlled encapsulation method that fully fixes and confines IONPs of various sizes within the metal–organic frameworks (MOFs). This novel carrier preserves the MOF's morphology, porosity, and IONP segregation, while enhances heating efficiency through the oxidation of antiferromagnetic phases in IONPs during encapsulation. It also features a magnetothermally-responsive nanobrush that is stimulated by an alternating magnetic field to enable on-demand drug release. The novel carrier shows improved heating, which has potential applications as contrast agents and for combined chemo and magnetic hyperthermia therapy. It holds a great promise for magneto-thermally modulated drug dosing at tumor sites, making it an exciting avenue for cancer treatment.
AB - The development of external stimuli-controlled payload systems has been sought after with increasing interest toward magnetothermally-triggered drug release (MTDR) carriers due to their non-invasive features. However, current MTDR carriers present several limitations, such as poor heating efficiency caused by the aggregation of iron oxide nanoparticles (IONPs) or the presence of antiferromagnetic phases which affect their efficiency. Herein, a novel MTDR carrier is developed using a controlled encapsulation method that fully fixes and confines IONPs of various sizes within the metal–organic frameworks (MOFs). This novel carrier preserves the MOF's morphology, porosity, and IONP segregation, while enhances heating efficiency through the oxidation of antiferromagnetic phases in IONPs during encapsulation. It also features a magnetothermally-responsive nanobrush that is stimulated by an alternating magnetic field to enable on-demand drug release. The novel carrier shows improved heating, which has potential applications as contrast agents and for combined chemo and magnetic hyperthermia therapy. It holds a great promise for magneto-thermally modulated drug dosing at tumor sites, making it an exciting avenue for cancer treatment.
KW - hyperthermia treatment
KW - iron oxide nanoparticles
KW - magnetothermal
KW - metal–organic frameworks
KW - on-demand drug release
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U2 - 10.1002/smll.202306940
DO - 10.1002/smll.202306940
M3 - Article
C2 - 38127968
AN - SCOPUS:85180173271
SN - 1613-6810
VL - 20
JO - Small
JF - Small
IS - 12
M1 - 2306940
ER -