Metallofullerene nanoparticles promote osteogenic differentiation of bone marrow stromal cells through BMP signaling pathway

Kangning Yang, Weipeng Cao, Xiaohong Hao, Xue Xue, Jing Zhao, Juan Liu, Yuliang Zhao, Jie Meng, Baoyun Sun, Jinchao Zhang, Xing Jie Liang

Research output: Contribution to journalArticle

43 Scopus citations

Abstract

Although endohedral metallofullerenol [Gd@C82(OH) 22]n nanoparticles have anti-tumor efficiency and mostly deposit in the bones of mice, how these nanoparticles act in bone marrow stromal cells (MSCs) remains largely unknown. Herein, we observed that [Gd@C 82(OH)22]n nanoparticles facilitated the differentiation of MSCs toward osteoblasts, as evidenced by the enhancement of alkaline phosphatase (ALP) activity and mineralized nodule formation upon [Gd@C82(OH)22]n nanoparticle treatment. Mechanistically, the effect of [Gd@C82(OH)22]n nanoparticles on ALP activity was inhibited by the addition of noggin as an inhibitor of the BMP signaling pathway. Moreover, the in vivo results of the ovariectomized rats further indicated that [Gd@C82(OH) 22]n nanoparticles effectively improved bone density and prevented osteoporosis.

Original languageEnglish (US)
Pages (from-to)1205-1212
Number of pages8
JournalNanoscale
Volume5
Issue number3
DOIs
StatePublished - Feb 7 2013

ASJC Scopus subject areas

  • Materials Science(all)

Fingerprint Dive into the research topics of 'Metallofullerene nanoparticles promote osteogenic differentiation of bone marrow stromal cells through BMP signaling pathway'. Together they form a unique fingerprint.

Cite this