Metabolism of the systemic fungicides 2-methylbenzanilide and 2-chlorobenzanilide by Rhizopus japonicus

P. R. Wallnöfer, S. Safe, O. Hutzinger

Research output: Contribution to journalArticle

14 Scopus citations

Abstract

Rhizopus japonicus convert the systemic fungicides 2-methylbenzanilide (BAS-305) and 2-chlorobenzanilide (BAS-307) into the corresponding p-hydroxyanilino derivatives (i.e., 2-methyl-4′-hydroxybenzanilide and 2-chloro-4′-hydroxybenzanilide). The structures of the metabolites were elucidated by nuclear magnetic resonance and mass spectrometric analysis and confirmed by synthesis. Metabolites appeared with the beginning of the exponential growth-phase and highest concentrations were reached when fungal growth ended.

Original languageEnglish (US)
Pages (from-to)458-463
Number of pages6
JournalPesticide Biochemistry and Physiology
Volume1
Issue number3-4
DOIs
StatePublished - Dec 1971

ASJC Scopus subject areas

  • Agronomy and Crop Science
  • Health, Toxicology and Mutagenesis

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