Rhizopus japonicus convert the systemic fungicides 2-methylbenzanilide (BAS-305) and 2-chlorobenzanilide (BAS-307) into the corresponding p-hydroxyanilino derivatives (i.e., 2-methyl-4′-hydroxybenzanilide and 2-chloro-4′-hydroxybenzanilide). The structures of the metabolites were elucidated by nuclear magnetic resonance and mass spectrometric analysis and confirmed by synthesis. Metabolites appeared with the beginning of the exponential growth-phase and highest concentrations were reached when fungal growth ended.
ASJC Scopus subject areas
- Agronomy and Crop Science
- Health, Toxicology and Mutagenesis