Metabolism of propachlor by the germfree rat

Jerome E. Bakke; Jan Åke Gustafsson; Bengt E. Gustafsson

doi:10.1126/science.7433983

Metabolism of propachlor by the germfree rat

Jerome E. Bakke, Jan Åke Gustafsson, Bengt E. Gustafsson

Houston Methodist

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Abstract

Three major metabolites of propachlor were isolated from the excreta of germfree rats given ¹⁴C-labeled propachlor orally. In contrast, 11 urinary metabolites, six of which were 2-methylsulfonylacetanilides not present in excreta of germfree rats, were isolated from control rats given ¹⁴C-labeled propachlor orally. Enterohepatic circulation and microbial metabolism in the intestine were necessary for production of the methylsulfonyl-containing and other metabolites of propachlor in the conventional rat.

Original language	English (US)
Pages (from-to)	433-435
Number of pages	3
Journal	Science
Volume	210
Issue number	4468
DOIs	https://doi.org/10.1126/science.7433983
State	Published - 1980

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title = "Metabolism of propachlor by the germfree rat",

abstract = "Three major metabolites of propachlor were isolated from the excreta of germfree rats given 14C-labeled propachlor orally. In contrast, 11 urinary metabolites, six of which were 2-methylsulfonylacetanilides not present in excreta of germfree rats, were isolated from control rats given 14C-labeled propachlor orally. Enterohepatic circulation and microbial metabolism in the intestine were necessary for production of the methylsulfonyl-containing and other metabolites of propachlor in the conventional rat.",

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year = "1980",

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AU - Bakke, Jerome E.

AU - Gustafsson, Jan Åke

AU - Gustafsson, Bengt E.

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N2 - Three major metabolites of propachlor were isolated from the excreta of germfree rats given 14C-labeled propachlor orally. In contrast, 11 urinary metabolites, six of which were 2-methylsulfonylacetanilides not present in excreta of germfree rats, were isolated from control rats given 14C-labeled propachlor orally. Enterohepatic circulation and microbial metabolism in the intestine were necessary for production of the methylsulfonyl-containing and other metabolites of propachlor in the conventional rat.

AB - Three major metabolites of propachlor were isolated from the excreta of germfree rats given 14C-labeled propachlor orally. In contrast, 11 urinary metabolites, six of which were 2-methylsulfonylacetanilides not present in excreta of germfree rats, were isolated from control rats given 14C-labeled propachlor orally. Enterohepatic circulation and microbial metabolism in the intestine were necessary for production of the methylsulfonyl-containing and other metabolites of propachlor in the conventional rat.

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Metabolism of propachlor by the germfree rat

Abstract

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