Metabolism of propachlor by the germfree rat

Jerome E. Bakke, Jan-Ake Gustafsson, Bengt E. Gustafsson

Research output: Contribution to journalArticle

47 Scopus citations

Abstract

Three major metabolites of propachlor were isolated from the excreta of germfree rats given 14C-labeled propachlor orally. In contrast, 11 urinary metabolites, six of which were 2-methylsulfonylacetanilides not present in excreta of germfree rats, were isolated from control rats given 14C-labeled propachlor orally. Enterohepatic circulation and microbial metabolism in the intestine were necessary for production of the methylsulfonyl-containing and other metabolites of propachlor in the conventional rat.

Original languageEnglish (US)
Pages (from-to)433-435
Number of pages3
JournalScience
Volume210
Issue number4468
DOIs
StatePublished - Jan 1 1980

ASJC Scopus subject areas

  • General

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