TY - JOUR
T1 - Metabolism of propachlor by the germfree rat
AU - Bakke, Jerome E.
AU - Gustafsson, Jan-Ake
AU - Gustafsson, Bengt E.
PY - 1980/1/1
Y1 - 1980/1/1
N2 - Three major metabolites of propachlor were isolated from the excreta of germfree rats given 14C-labeled propachlor orally. In contrast, 11 urinary metabolites, six of which were 2-methylsulfonylacetanilides not present in excreta of germfree rats, were isolated from control rats given 14C-labeled propachlor orally. Enterohepatic circulation and microbial metabolism in the intestine were necessary for production of the methylsulfonyl-containing and other metabolites of propachlor in the conventional rat.
AB - Three major metabolites of propachlor were isolated from the excreta of germfree rats given 14C-labeled propachlor orally. In contrast, 11 urinary metabolites, six of which were 2-methylsulfonylacetanilides not present in excreta of germfree rats, were isolated from control rats given 14C-labeled propachlor orally. Enterohepatic circulation and microbial metabolism in the intestine were necessary for production of the methylsulfonyl-containing and other metabolites of propachlor in the conventional rat.
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U2 - 10.1126/science.7433983
DO - 10.1126/science.7433983
M3 - Article
C2 - 7433983
AN - SCOPUS:0019161325
VL - 210
SP - 433
EP - 435
JO - Science (New York, N.Y.)
JF - Science (New York, N.Y.)
SN - 0036-8075
IS - 4468
ER -