Metabolism of propachlor by the germfree rat

Jerome E. Bakke, Jan Åke Gustafsson, Bengt E. Gustafsson

Research output: Contribution to journalArticlepeer-review

49 Scopus citations


Three major metabolites of propachlor were isolated from the excreta of germfree rats given 14C-labeled propachlor orally. In contrast, 11 urinary metabolites, six of which were 2-methylsulfonylacetanilides not present in excreta of germfree rats, were isolated from control rats given 14C-labeled propachlor orally. Enterohepatic circulation and microbial metabolism in the intestine were necessary for production of the methylsulfonyl-containing and other metabolites of propachlor in the conventional rat.

Original languageEnglish (US)
Pages (from-to)433-435
Number of pages3
Issue number4468
StatePublished - 1980

ASJC Scopus subject areas

  • General


Dive into the research topics of 'Metabolism of propachlor by the germfree rat'. Together they form a unique fingerprint.

Cite this