TY - JOUR
T1 - Metabolism of high density lipoproteins
AU - Patsch, Josef R.
AU - Gotto, Antonio
PY - 1987/1/1
Y1 - 1987/1/1
N2 - This chapter highlights high-density lipoproteins (HDL) metabolism in humans. HDL concentration in plasma is expressed as HDL cholesterol that remains in the supernatant after precipitation of the apolipoprotein (apo)B-containing lipoproteins and represents a minor fraction of cholesterol in plasma. HDL particles have a spherical shape and possess a core of neutral lipids comprising mostly of cholesteryl esters. Variable amounts of triglycerides are present in the core, depending on the plasma triglyceride levels. The hydrophobic core is surrounded by a surface monolayer consisting of phospholipids, cholesterol, and apolipoproteins. HDL particles are heterogeneous with respect to size, composition, and density. The two major apolipoproteins in HDL are apoA-I and apoA-II. The primary translation product of human apoA-I mRNA possesses an additional peptide that contains 18 amino acids that is cleaved intracellularly by a signal peptidase of the endoplasmic reticulum leaving pro-apoA. The apoA-I gene contains six homologous tandemly repeated 66 bp regions indicating internal gene duplication.
AB - This chapter highlights high-density lipoproteins (HDL) metabolism in humans. HDL concentration in plasma is expressed as HDL cholesterol that remains in the supernatant after precipitation of the apolipoprotein (apo)B-containing lipoproteins and represents a minor fraction of cholesterol in plasma. HDL particles have a spherical shape and possess a core of neutral lipids comprising mostly of cholesteryl esters. Variable amounts of triglycerides are present in the core, depending on the plasma triglyceride levels. The hydrophobic core is surrounded by a surface monolayer consisting of phospholipids, cholesterol, and apolipoproteins. HDL particles are heterogeneous with respect to size, composition, and density. The two major apolipoproteins in HDL are apoA-I and apoA-II. The primary translation product of human apoA-I mRNA possesses an additional peptide that contains 18 amino acids that is cleaved intracellularly by a signal peptidase of the endoplasmic reticulum leaving pro-apoA. The apoA-I gene contains six homologous tandemly repeated 66 bp regions indicating internal gene duplication.
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U2 - 10.1016/S0167-7306(08)60201-X
DO - 10.1016/S0167-7306(08)60201-X
M3 - Article
AN - SCOPUS:77957224584
VL - 14
SP - 221
EP - 259
JO - New Comprehensive Biochemistry
JF - New Comprehensive Biochemistry
SN - 0167-7306
IS - C
ER -