Metabolism of Chlorobiphenyls in the Goat and Cow

Stephen Safe, Nicholas Platonow, Otto Hutzinger

Research output: Contribution to journalArticle

34 Scopus citations

Abstract

4-Chlorobiphenyl and 4,4′-dichlorobiphenyl were administered to goats by intravenous injection and mass spectrometric analysis indicated the presence of oxygenated chlorobiphenyl metabolites in the urine. The urinary metabolites of 4-chlorobiphenyl were isolated and their structures shown to be 4′-chloro-4-biphenylol and 4′-chloro-3,4-biphenyldiol. The former metabolite was also identified in urine from a cow which was orally fed 4-chlorobiphenyl. The only urinary metabolite of 4,4′-dichlorobiphenyl was identified as 4,4′-dichloro-3-biphenylol. The structures of all the metabolites were confirmed by nuclear magnetic resonance spectrometry and by comparison with samples of the metabolites which have been identified in the rat and confirmed by synthesis. Analysis of extracts from the feces and several organs of the goats did not reveal any of the metabolites which were identified in the urine. The results thus for the first time indicate a metabolic pathway for PCB's in domestic animals and the excretion of these metabolites in the urine.

Original languageEnglish (US)
Pages (from-to)259-261
Number of pages3
JournalJournal of Agricultural and Food Chemistry
Volume23
Issue number2
DOIs
StatePublished - Mar 1 1975

ASJC Scopus subject areas

  • Chemistry(all)
  • Agricultural and Biological Sciences(all)

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