TY - JOUR
T1 - Metabolism of apolipoproteins A‐I and A‐ll and its influence on the high density lipoprotein subfraction distribution in males and females
AU - SHEPHERD, JAMES
AU - PACKARD, CHRISTOPHER J.
AU - PATSCH, JOSEF R.
AU - GOTTO, ANTONIO M.
AU - TAUNTON, O. DAVID
PY - 1978/6
Y1 - 1978/6
N2 - Rate zonal ultracentrifugation of plasma samples from ten healthy age-matched volunteers (five males, five females) indicated that the high density lipoprotein subfraction ratio (HDL 2:HDL 3) in females was significantly higher than in males. The cause of this phenomenon was investigated by simultaneous examination of the metabolism of the major HDL apoproteins (apoA-I and apoA-II) in both groups. The results show that there is no significant sex-related difference in the plasma pool size, fractional catabolic rate, or synthetic rate of either apoprotein. We conclude that the increased HDL 2:HDL 3 ratio in females versus males does not derive from measurable differences in the metabolic handling of either apoprotein.
AB - Rate zonal ultracentrifugation of plasma samples from ten healthy age-matched volunteers (five males, five females) indicated that the high density lipoprotein subfraction ratio (HDL 2:HDL 3) in females was significantly higher than in males. The cause of this phenomenon was investigated by simultaneous examination of the metabolism of the major HDL apoproteins (apoA-I and apoA-II) in both groups. The results show that there is no significant sex-related difference in the plasma pool size, fractional catabolic rate, or synthetic rate of either apoprotein. We conclude that the increased HDL 2:HDL 3 ratio in females versus males does not derive from measurable differences in the metabolic handling of either apoprotein.
KW - HDL and HDL
KW - Rate zonal ultracentrifugation
KW - absolute catabolic rate
KW - fractional catabolic rate
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U2 - 10.1111/j.1365-2362.1978.tb00823.x
DO - 10.1111/j.1365-2362.1978.tb00823.x
M3 - Article
C2 - 211035
AN - SCOPUS:0018139663
SN - 0014-2972
VL - 8
SP - 115
EP - 120
JO - European Journal of Clinical Investigation
JF - European Journal of Clinical Investigation
IS - 3
ER -