Metabolism of apolipoproteins A‐I and A‐ll and its influence on the high density lipoprotein subfraction distribution in males and females

JAMES SHEPHERD, CHRISTOPHER J. PACKARD, JOSEF R. PATSCH, Antonio Gotto, O. DAVID TAUNTON

Research output: Contribution to journalArticle

32 Scopus citations

Abstract

Rate zonal ultracentrifugation of plasma samples from ten healthy age-matched volunteers (five males, five females) indicated that the high density lipoprotein subfraction ratio (HDL 2:HDL 3) in females was significantly higher than in males. The cause of this phenomenon was investigated by simultaneous examination of the metabolism of the major HDL apoproteins (apoA-I and apoA-II) in both groups. The results show that there is no significant sex-related difference in the plasma pool size, fractional catabolic rate, or synthetic rate of either apoprotein. We conclude that the increased HDL 2:HDL 3 ratio in females versus males does not derive from measurable differences in the metabolic handling of either apoprotein.

Original languageEnglish (US)
Pages (from-to)115-120
Number of pages6
JournalEuropean Journal of Clinical Investigation
Volume8
Issue number3
DOIs
StatePublished - Jan 1 1978

Keywords

  • HDL and HDL
  • Rate zonal ultracentrifugation
  • absolute catabolic rate
  • fractional catabolic rate

ASJC Scopus subject areas

  • Biochemistry
  • Clinical Biochemistry

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