Metabolism of 2-acetamido-4-(chloromethyl)thiazole in germfree and conventional rats

J. E. Bakke; J. J. Rafter; P. Lindeskog; V. J. Feil; J. Å Gustafsson; B. E. Gustafsson

doi:10.1016/0006-2952(81)90020-4

Metabolism of 2-acetamido-4-(chloromethyl)thiazole in germfree and conventional rats

J. E. Bakke, J. J. Rafter, P. Lindeskog, V. J. Feil, J. Å Gustafsson, B. E. Gustafsson

Houston Methodist

Research output: Contribution to journal › Article › peer-review

19 Scopus citations

Abstract

In contrast with conventional rats, 2-acetamido-4-(chloromethyl)thiazole was not metabolized to the 4-(methylthiomethyl)-, 4-(methylsulfinylmethyl)- and 4-(methylsulfonylmethyl) analogues by germfree rats. Mechanisms for the formation of these metabolites from the mercapturate and the S-glucuronide are proposed. These mechanisms involve the biliary excretion of a mercapturic acid conjugate and an S-glucuronide conjugate which are metabolized in the intestine to metabolites that are reabsorbed, metabolized and excreted with the urine.

Original language	English (US)
Pages (from-to)	1839-1844
Number of pages	6
Journal	Biochemical pharmacology
Volume	30
Issue number	13
DOIs	https://doi.org/10.1016/0006-2952(81)90020-4
State	Published - Jul 1 1981

ASJC Scopus subject areas

Biochemistry
Pharmacology

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title = "Metabolism of 2-acetamido-4-(chloromethyl)thiazole in germfree and conventional rats",

abstract = "In contrast with conventional rats, 2-acetamido-4-(chloromethyl)thiazole was not metabolized to the 4-(methylthiomethyl)-, 4-(methylsulfinylmethyl)- and 4-(methylsulfonylmethyl) analogues by germfree rats. Mechanisms for the formation of these metabolites from the mercapturate and the S-glucuronide are proposed. These mechanisms involve the biliary excretion of a mercapturic acid conjugate and an S-glucuronide conjugate which are metabolized in the intestine to metabolites that are reabsorbed, metabolized and excreted with the urine.",

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AU - Bakke, J. E.

AU - Rafter, J. J.

AU - Lindeskog, P.

AU - Feil, V. J.

AU - Gustafsson, J. Å

AU - Gustafsson, B. E.

PY - 1981/7/1

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N2 - In contrast with conventional rats, 2-acetamido-4-(chloromethyl)thiazole was not metabolized to the 4-(methylthiomethyl)-, 4-(methylsulfinylmethyl)- and 4-(methylsulfonylmethyl) analogues by germfree rats. Mechanisms for the formation of these metabolites from the mercapturate and the S-glucuronide are proposed. These mechanisms involve the biliary excretion of a mercapturic acid conjugate and an S-glucuronide conjugate which are metabolized in the intestine to metabolites that are reabsorbed, metabolized and excreted with the urine.

AB - In contrast with conventional rats, 2-acetamido-4-(chloromethyl)thiazole was not metabolized to the 4-(methylthiomethyl)-, 4-(methylsulfinylmethyl)- and 4-(methylsulfonylmethyl) analogues by germfree rats. Mechanisms for the formation of these metabolites from the mercapturate and the S-glucuronide are proposed. These mechanisms involve the biliary excretion of a mercapturic acid conjugate and an S-glucuronide conjugate which are metabolized in the intestine to metabolites that are reabsorbed, metabolized and excreted with the urine.

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Metabolism of 2-acetamido-4-(chloromethyl)thiazole in germfree and conventional rats

Abstract

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