Metabolism of 2-acetamido-4-(chloromethyl)thiazole in germfree and conventional rats

J. E. Bakke, J. J. Rafter, P. Lindeskog, V. J. Feil, J. Å Gustafsson, B. E. Gustafsson

Research output: Contribution to journalArticle

19 Scopus citations

Abstract

In contrast with conventional rats, 2-acetamido-4-(chloromethyl)thiazole was not metabolized to the 4-(methylthiomethyl)-, 4-(methylsulfinylmethyl)- and 4-(methylsulfonylmethyl) analogues by germfree rats. Mechanisms for the formation of these metabolites from the mercapturate and the S-glucuronide are proposed. These mechanisms involve the biliary excretion of a mercapturic acid conjugate and an S-glucuronide conjugate which are metabolized in the intestine to metabolites that are reabsorbed, metabolized and excreted with the urine.

Original languageEnglish (US)
Pages (from-to)1839-1844
Number of pages6
JournalBiochemical pharmacology
Volume30
Issue number13
DOIs
StatePublished - Jul 1 1981

ASJC Scopus subject areas

  • Biochemistry
  • Pharmacology

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