Abstract
Mutagenic and carcinogenic heterocyclic aromatic amines are formed in protein-rich food cooked under household conditions. The compounds have been shown to be activated mainly by cytochromes P-450IA1 and IA2. In the conventional rat, these P-450 enzymes were increased in the intestinal mucosa following oral administration of fried meat at a level comparable to human consumption. No such increase was observed in germfree rats. Furthermore, the metabolic disposition of the mutagenic material differed between the germfree and the conventional animals. A different urinary pattern of mutagenic metabolites and a substantially lower fecal mutagen excretion was observed in the germfree rats. The results implies a role of the intestinal microflora in the metabolism of fried meat mutagens.
Original language | English (US) |
---|---|
Pages (from-to) | 45-49 |
Number of pages | 5 |
Journal | Acta Chirurgica Scandinavica, Supplement |
Volume | 157 |
Issue number | 562 |
State | Published - 1991 |
ASJC Scopus subject areas
- Surgery