Metabolic Effects of Endoscopic Duodenal Mucosal Resurfacing: a Systematic Review and Meta-analysis

Guilherme Henrique Peixoto de Oliveira; Diogo Turiani Hourneaux de Moura; Mateus Pereira Funari; Thomas R. McCarty; Igor Braga Ribeiro; Wanderley Marques Bernardo; Vitor Massaro Takamatsu Sagae; João Remi Freitas; Gabriel Mayo de Vieira Souza; Eduardo Guimarães Hourneaux de Moura

doi:10.1007/s11695-020-05170-3

Metabolic Effects of Endoscopic Duodenal Mucosal Resurfacing: a Systematic Review and Meta-analysis

Guilherme Henrique Peixoto de Oliveira, Diogo Turiani Hourneaux de Moura, Mateus Pereira Funari, Thomas R. McCarty, Igor Braga Ribeiro, Wanderley Marques Bernardo, Vitor Massaro Takamatsu Sagae, João Remi Freitas, Gabriel Mayo de Vieira Souza, Eduardo Guimarães Hourneaux de Moura

Research output: Contribution to journal › Review article › peer-review

44 Scopus citations

Abstract

Duodenal mucosal resurfacing (DMR) is an innovative endoscopic bariatric and metabolic therapy (EBMT) emerging in recent years. It uses the duodenum to achieve better glycemic and weight control. This study aimed to evaluate in a critical and systematic way the metabolic effects of this procedure. Electronic searches were performed evaluating the DMR procedure based on predefined inclusion and exclusion criteria. Changes in measured outcomes were evaluated using random-effects models by computing weighted mean differences (MD) and corresponding 95% CIs between pre-and post-procedure metabolic characteristics. Four studies were selected for qualitative and quantitative analysis. DMR demonstrated beneficial glycemic and hepatic metabolic effects among patients with non-insulin dependent type 2 diabetes (T2D) at 3 and 6 months post-procedure.

Original language	English (US)
Pages (from-to)	1304-1312
Number of pages	9
Journal	Obesity Surgery
Volume	31
Issue number	3
DOIs	https://doi.org/10.1007/s11695-020-05170-3
State	Published - Mar 2021

Keywords

Diabetes
DMR
Duodenal mucosal resurfacing
Hepatic steatosis
Hydrothermal ablation
Systematic review

ASJC Scopus subject areas

Surgery
Endocrinology, Diabetes and Metabolism
Nutrition and Dietetics

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title = "Metabolic Effects of Endoscopic Duodenal Mucosal Resurfacing: a Systematic Review and Meta-analysis",

abstract = "Duodenal mucosal resurfacing (DMR) is an innovative endoscopic bariatric and metabolic therapy (EBMT) emerging in recent years. It uses the duodenum to achieve better glycemic and weight control. This study aimed to evaluate in a critical and systematic way the metabolic effects of this procedure. Electronic searches were performed evaluating the DMR procedure based on predefined inclusion and exclusion criteria. Changes in measured outcomes were evaluated using random-effects models by computing weighted mean differences (MD) and corresponding 95\% CIs between pre-and post-procedure metabolic characteristics. Four studies were selected for qualitative and quantitative analysis. DMR demonstrated beneficial glycemic and hepatic metabolic effects among patients with non-insulin dependent type 2 diabetes (T2D) at 3 and 6 months post-procedure.",

keywords = "Diabetes, DMR, Duodenal mucosal resurfacing, Hepatic steatosis, Hydrothermal ablation, Systematic review",

author = "\{de Oliveira\}, \{Guilherme Henrique Peixoto\} and \{de Moura\}, \{Diogo Turiani Hourneaux\} and Funari, \{Mateus Pereira\} and McCarty, \{Thomas R.\} and Ribeiro, \{Igor Braga\} and Bernardo, \{Wanderley Marques\} and Sagae, \{Vitor Massaro Takamatsu\} and Freitas, \{Jo{\~a}o Remi\} and Souza, \{Gabriel Mayo de Vieira\} and \{de Moura\}, \{Eduardo Guimar{\~a}es Hourneaux\}",

note = "Publisher Copyright: {\textcopyright} 2021, The Author(s), under exclusive licence to Springer Science+Business Media, LLC part of Springer Nature.",

year = "2021",

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doi = "10.1007/s11695-020-05170-3",

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AU - de Moura, Diogo Turiani Hourneaux

AU - Funari, Mateus Pereira

AU - McCarty, Thomas R.

AU - Ribeiro, Igor Braga

AU - Bernardo, Wanderley Marques

AU - Sagae, Vitor Massaro Takamatsu

AU - Freitas, João Remi

AU - Souza, Gabriel Mayo de Vieira

AU - de Moura, Eduardo Guimarães Hourneaux

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AB - Duodenal mucosal resurfacing (DMR) is an innovative endoscopic bariatric and metabolic therapy (EBMT) emerging in recent years. It uses the duodenum to achieve better glycemic and weight control. This study aimed to evaluate in a critical and systematic way the metabolic effects of this procedure. Electronic searches were performed evaluating the DMR procedure based on predefined inclusion and exclusion criteria. Changes in measured outcomes were evaluated using random-effects models by computing weighted mean differences (MD) and corresponding 95% CIs between pre-and post-procedure metabolic characteristics. Four studies were selected for qualitative and quantitative analysis. DMR demonstrated beneficial glycemic and hepatic metabolic effects among patients with non-insulin dependent type 2 diabetes (T2D) at 3 and 6 months post-procedure.

KW - Diabetes

KW - DMR

KW - Duodenal mucosal resurfacing

KW - Hepatic steatosis

KW - Hydrothermal ablation

KW - Systematic review

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Metabolic Effects of Endoscopic Duodenal Mucosal Resurfacing: a Systematic Review and Meta-analysis

Abstract

Keywords

ASJC Scopus subject areas

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