Metabolic Effects of Endoscopic Duodenal Mucosal Resurfacing: a Systematic Review and Meta-analysis

Guilherme Henrique Peixoto de Oliveira, Diogo Turiani Hourneaux de Moura, Mateus Pereira Funari, Thomas R. McCarty, Igor Braga Ribeiro, Wanderley Marques Bernardo, Vitor Massaro Takamatsu Sagae, João Remi Freitas, Gabriel Mayo de Vieira Souza, Eduardo Guimarães Hourneaux de Moura

Research output: Contribution to journalReview articlepeer-review

22 Scopus citations


Duodenal mucosal resurfacing (DMR) is an innovative endoscopic bariatric and metabolic therapy (EBMT) emerging in recent years. It uses the duodenum to achieve better glycemic and weight control. This study aimed to evaluate in a critical and systematic way the metabolic effects of this procedure. Electronic searches were performed evaluating the DMR procedure based on predefined inclusion and exclusion criteria. Changes in measured outcomes were evaluated using random-effects models by computing weighted mean differences (MD) and corresponding 95% CIs between pre-and post-procedure metabolic characteristics. Four studies were selected for qualitative and quantitative analysis. DMR demonstrated beneficial glycemic and hepatic metabolic effects among patients with non-insulin dependent type 2 diabetes (T2D) at 3 and 6 months post-procedure.

Original languageEnglish (US)
Pages (from-to)1304-1312
Number of pages9
JournalObesity Surgery
Issue number3
StatePublished - Mar 2021


  • Diabetes
  • DMR
  • Duodenal mucosal resurfacing
  • Hepatic steatosis
  • Hydrothermal ablation
  • Systematic review

ASJC Scopus subject areas

  • Surgery
  • Endocrinology, Diabetes and Metabolism
  • Nutrition and Dietetics


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