Metabolic Dysfunction-Associated Steatotic Liver Disease and Metabolic Dysfunction-Associated Steatohepatitis: The Patient and Physician Perspective

Wayne Eskridge, Donna R. Cryer, Jörn M. Schattenberg, Amalia Gastaldelli, Harmeet Malhi, Alina M. Allen, Mazen Noureddin, Arun J. Sanyal

Research output: Contribution to journalReview articlepeer-review

7 Scopus citations

Abstract

Diagnosing and managing metabolic dysfunction-associated steatotic liver disease (MASLD) remains a major challenge in primary care due to lack of agreement on diagnostic tools, difficulty in identifying symptoms and determining their cause, absence of approved pharmacological treatments, and limited awareness of the disease. However, prompt diagnosis and management are critical to preventing MASLD from progressing to more severe forms of liver disease. This highlights the need to raise awareness and improve understanding of MASLD among both patients and physicians. The patient perspective is invaluable to advancing our knowledge of this disease and how to manage it, as their perspectives have led to the growing recognition that patients experience subtle symptoms and that patient-reported outcomes should be incorporated into drug development. This review and expert opinion examine MASLD and metabolic dysfunction-associated steatohepatitis from the patient and physician perspective from pre-diagnosis to diagnosis and early care, through to progression to advanced liver damage. Specifically, the paper dives into the issues patients and physicians experience, and, in turn, what is required to improve diagnosis and management, including tips and tools to empower patients and physicians dealing with MASLD.

Original languageEnglish (US)
Article number6216
JournalJournal of Clinical Medicine
Volume12
Issue number19
DOIs
StatePublished - Sep 26 2023

Keywords

  • advocacy
  • cirrhosis
  • fatty liver
  • liver disease
  • metabolic dysfunction-associated steatohepatitis
  • metabolic dysfunction-associated steatotic liver disease
  • outcome
  • primary care physicians
  • quality of life

ASJC Scopus subject areas

  • Medicine(all)

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