TY - JOUR
T1 - Mesoporous silicon particles as intravascular drug delivery vectors
T2 - Fabrication, in-vitro, and in-vivo assessments
AU - Chiappini, Ciro
AU - Tasciotti, Ennio
AU - Serda, Rita
AU - Brousseau, Lou
AU - Liu, Xuewu
AU - Ferrari, Mauro
PY - 2011/6/1
Y1 - 2011/6/1
N2 - Porous silicon is an attractive biomaterial for drug delivery thanks to its biocompatibility, biodegradability, ease of fabrication, tunable nanostructure, and porous network. Herein we briefly present the development of a multi-stage delivery vector that leverages these advantages to enhance delivery of systemically administered therapeutic agents. We illustrate the rational design, objective-oriented fabrication and geometric control of first stage porous silicon microparticles. We describe how geometry affects the biodistribution of first stage vectors and how their porous structure affects the loading and release of second stage theranostic payloads. We describe the mechanism of cellular internalization and intracellular trafficking of particles. Finally we present two multi-stage vector prototypes for the delivery of magnetic resonance imaging contrast agents and small interfering RNA.
AB - Porous silicon is an attractive biomaterial for drug delivery thanks to its biocompatibility, biodegradability, ease of fabrication, tunable nanostructure, and porous network. Herein we briefly present the development of a multi-stage delivery vector that leverages these advantages to enhance delivery of systemically administered therapeutic agents. We illustrate the rational design, objective-oriented fabrication and geometric control of first stage porous silicon microparticles. We describe how geometry affects the biodistribution of first stage vectors and how their porous structure affects the loading and release of second stage theranostic payloads. We describe the mechanism of cellular internalization and intracellular trafficking of particles. Finally we present two multi-stage vector prototypes for the delivery of magnetic resonance imaging contrast agents and small interfering RNA.
KW - Biomaterial
KW - Drug delivery
KW - Multi-stage vector
KW - Porous silicon
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U2 - 10.1002/pssc.201000344
DO - 10.1002/pssc.201000344
M3 - Article
AN - SCOPUS:79959652673
VL - 8
SP - 1826
EP - 1832
JO - Physica Status Solidi (C) Current Topics in Solid State Physics
JF - Physica Status Solidi (C) Current Topics in Solid State Physics
SN - 1862-6351
IS - 6
ER -