Mesoporous silicon particles as a multistage delivery system for imaging and therapeutic applications

Ennio Tasciotti, Xuewu Liu, Rohan Bhavane, Kevin Plant, Ashley D. Leonard, B. Katherine Price, Mark Ming Cheng Cheng, Paolo Decuzzi, James M. Tour, Fredika Robertson, Mauro Ferrari

Research output: Contribution to journalArticle

529 Scopus citations

Abstract

Many nanosized particulate systems are being developed as intravascular carriers to increase the levels of therapeutic agents delivered to targets, with the fewest side effects. The surface of these carriers is often functionalized with biological recognition molecules for specific, targeted delivery. However, there are a series of biological barriers in the body that prevent these carriers from localizing at their targets at sufficiently high therapeutic concentrations. Here we show a multistage delivery system that can carry, release over time and deliver two types of nanoparticles into primary endothelial cells. The multistage delivery system is based on biodegradable and biocompatible mesoporous silicon particles that have well-controlled shapes, sizes and pores. The use of this system is envisioned to open new avenues for avoiding biological barriers and delivering more than one therapeutic agent to the target at a time, in a time-controlled fashion.

Original languageEnglish (US)
Pages (from-to)151-157
Number of pages7
JournalNature Nanotechnology
Volume3
Issue number3
DOIs
StatePublished - Jan 1 2008

ASJC Scopus subject areas

  • Bioengineering
  • Atomic and Molecular Physics, and Optics
  • Biomedical Engineering
  • Materials Science(all)
  • Condensed Matter Physics
  • Electrical and Electronic Engineering

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