TY - JOUR
T1 - Mesoporous silicon particles as a multistage delivery system for imaging and therapeutic applications
AU - Tasciotti, Ennio
AU - Liu, Xuewu
AU - Bhavane, Rohan
AU - Plant, Kevin
AU - Leonard, Ashley D.
AU - Price, B. Katherine
AU - Cheng, Mark Ming Cheng
AU - Decuzzi, Paolo
AU - Tour, James M.
AU - Robertson, Fredika
AU - Ferrari, Mauro
PY - 2008/1/1
Y1 - 2008/1/1
N2 - Many nanosized particulate systems are being developed as intravascular carriers to increase the levels of therapeutic agents delivered to targets, with the fewest side effects. The surface of these carriers is often functionalized with biological recognition molecules for specific, targeted delivery. However, there are a series of biological barriers in the body that prevent these carriers from localizing at their targets at sufficiently high therapeutic concentrations. Here we show a multistage delivery system that can carry, release over time and deliver two types of nanoparticles into primary endothelial cells. The multistage delivery system is based on biodegradable and biocompatible mesoporous silicon particles that have well-controlled shapes, sizes and pores. The use of this system is envisioned to open new avenues for avoiding biological barriers and delivering more than one therapeutic agent to the target at a time, in a time-controlled fashion.
AB - Many nanosized particulate systems are being developed as intravascular carriers to increase the levels of therapeutic agents delivered to targets, with the fewest side effects. The surface of these carriers is often functionalized with biological recognition molecules for specific, targeted delivery. However, there are a series of biological barriers in the body that prevent these carriers from localizing at their targets at sufficiently high therapeutic concentrations. Here we show a multistage delivery system that can carry, release over time and deliver two types of nanoparticles into primary endothelial cells. The multistage delivery system is based on biodegradable and biocompatible mesoporous silicon particles that have well-controlled shapes, sizes and pores. The use of this system is envisioned to open new avenues for avoiding biological barriers and delivering more than one therapeutic agent to the target at a time, in a time-controlled fashion.
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U2 - 10.1038/nnano.2008.34
DO - 10.1038/nnano.2008.34
M3 - Article
C2 - 18654487
AN - SCOPUS:40449122225
VL - 3
SP - 151
EP - 157
JO - Nature Nanotechnology
JF - Nature Nanotechnology
SN - 1748-3387
IS - 3
ER -