TY - JOUR
T1 - Mesoporous NaYbF4@NaGdF4 core-shell up-conversion nanoparticles for targeted drug delivery and multimodal imaging
AU - Zhou, Liangjun
AU - Zheng, Xiaopeng
AU - Gu, Zhanjun
AU - Yin, Wenyan
AU - Zhang, Xiao
AU - Ruan, Longfei
AU - Yang, Yanbo
AU - Hu, Zhongbo
AU - Zhao, Yuliang
PY - 2014/1/1
Y1 - 2014/1/1
N2 - We developed a facile strategy to obtain a new kind of mesoporous core-shell structured up-conversion nanoparticles (mUCNPs), composed of a NaYbF4:2%Er core and a mesoporous NaGdF4 shell. This mesoporous shell not only enhanced the up-conversion luminescence but also endowed many other functionalities of the nanoparticles such as drug delivery and bio-imaging capabilities. Moreover, after being conjugated with polyethylenimine (PEI) and folic acid (FA), core-shell mUCNPs exhibited good water dispersibility, enhanced drug delivery efficiency, and remarkable targeting ability to cancer cells. To certify the folate receptors (FR)-mediated targeted drug delivery, cell viability assay, cell up-conversion luminescence imaging and flow cytometry analysis were carried out. Furthermore, apart from the application for targeted drug delivery, the as-prepared core-shell mUCNPs could also be employed as the contrast agents for X-ray computed tomography (CT) and magnetic resonance (MR) imaging, because of the strong X-ray attenuation ability of Yb and high longitudinal molar relaxivity (r1) of Gd in the nanoparticles, providing the potential for simultaneously bio-imaging and cancer-targeting therapy.
AB - We developed a facile strategy to obtain a new kind of mesoporous core-shell structured up-conversion nanoparticles (mUCNPs), composed of a NaYbF4:2%Er core and a mesoporous NaGdF4 shell. This mesoporous shell not only enhanced the up-conversion luminescence but also endowed many other functionalities of the nanoparticles such as drug delivery and bio-imaging capabilities. Moreover, after being conjugated with polyethylenimine (PEI) and folic acid (FA), core-shell mUCNPs exhibited good water dispersibility, enhanced drug delivery efficiency, and remarkable targeting ability to cancer cells. To certify the folate receptors (FR)-mediated targeted drug delivery, cell viability assay, cell up-conversion luminescence imaging and flow cytometry analysis were carried out. Furthermore, apart from the application for targeted drug delivery, the as-prepared core-shell mUCNPs could also be employed as the contrast agents for X-ray computed tomography (CT) and magnetic resonance (MR) imaging, because of the strong X-ray attenuation ability of Yb and high longitudinal molar relaxivity (r1) of Gd in the nanoparticles, providing the potential for simultaneously bio-imaging and cancer-targeting therapy.
KW - Core-shell
KW - Mesoporous
KW - Multimodality biomedical imaging
KW - Targeted drug delivery
KW - Up-conversion nanoparticles
UR - http://www.scopus.com/inward/record.url?scp=84902533705&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84902533705&partnerID=8YFLogxK
U2 - 10.1016/j.biomaterials.2014.05.051
DO - 10.1016/j.biomaterials.2014.05.051
M3 - Article
C2 - 24929618
AN - SCOPUS:84902533705
VL - 35
SP - 7666
EP - 7678
JO - Biomaterials
JF - Biomaterials
SN - 0142-9612
IS - 26
ER -