Meso1, a basic-helix-loop-helix protein involved in mammalian presomitic mesoderm development

Michael A. Blanar, Philip H. Crossley, Kevin G. Peters, Eiríkur Steingrímsson, Neal G. Copeland, Nancy A. Jenkins, Gail R. Martin, William J. Rutter

Research output: Contribution to journalArticlepeer-review

41 Scopus citations

Abstract

To identify genes involved in the regulation of early mammalian development, we have developed a dominant-negative mutant basic-helix-loop- helix (bHLH) protein probe for interaction cloning and have isolated a member of the bHLH family of transcription factors, Meso1. Meso1-E2A heterodimers are capable of binding to oligonucleotide probes that contain a bHLH DNA recognition motif. In mouse embryos, Meso1 is expressed prior to MyoD1 family members. Meso1 expression is first detected at the neural plate stage of development in the paraxial mesoderm of the head and in presomitic mesodermal cells prior to their condensation into somites. Our findings suggest that Meso1 may be a key regulatory gene involved in the early events of vertebrate mesoderm differentiation.

Original languageEnglish (US)
Pages (from-to)5870-5874
Number of pages5
JournalProceedings of the National Academy of Sciences of the United States of America
Volume92
Issue number13
DOIs
StatePublished - Jun 20 1995

ASJC Scopus subject areas

  • General

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