Mesenchymal Tumors of the Mediastinum: An Update on Diagnostic Approach

Joon Hyuk Choi, Jae Y. Ro

Research output: Contribution to journalReview articlepeer-review


Mesenchymal tumors of the mediastinum are a heterogenous group of rare tumors with divergent lineages. Mediastinal mesenchymal tumors are diagnostically challenging due to their diversity and morphologic overlap with nonmesenchymal lesions arising in the mediastinum. Accurate histologic diagnosis is critical for appropriate patient management and prognostication. Many mediastinal mesenchymal tumors affect distinct age groups or occur at specific mediastinal compartments. Neurogenic tumors, liposarcoma, solitary fibrous tumor, and synovial sarcoma are common mesenchymal tumors in the mediastinum. Herein, we provide an update on the diagnostic approach to mediastinal mesenchymal tumors and a review of the histologic features and differential diagnosis of common benign and malignant mesenchymal tumors of the mediastinum.

Original languageEnglish (US)
Pages (from-to)351-381
Number of pages31
JournalAdvances in Anatomic Pathology
Issue number5
StatePublished - Sep 2021


  • mediastinum
  • mesenchymal tumor
  • pathology
  • soft tissue
  • thorax

ASJC Scopus subject areas

  • Anatomy
  • Pathology and Forensic Medicine


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