Mercapturic acid pathway metabolites of xenobiotics: generation of potentially toxic metabolites during enterohepatic circulation

Jerome Bakke; Jan Åke Gustafsson

doi:10.1016/0165-6147(84)90532-7

Mercapturic acid pathway metabolites of xenobiotics: generation of potentially toxic metabolites during enterohepatic circulation

Jerome Bakke, Jan Åke Gustafsson

Research output: Contribution to journal › Article › peer-review

47 Scopus citations

Abstract

The body detoxifies many xenobiotics via the mercapturic acid pathway (MAP). Unfortunately, in some cases this process provides intermediate metabolites that are substrates for mutagen/toxin-forming reactions - in particular reactive thiols. Jerome Bakke and Jan-Åke Gustafsson described this process of methylthiolation and the novel metabolic pathway involved. They highlight the increasing load of xenobiotics imposed by industrial processes and the toxicological consequences of their methylthiolated metabolites in individual organisms and the biosphere in general.

Original language	English (US)
Pages (from-to)	517-521
Number of pages	5
Journal	Trends in Pharmacological Sciences
Volume	5
Issue number	C
DOIs	https://doi.org/10.1016/0165-6147(84)90532-7
State	Published - 1984

ASJC Scopus subject areas

Toxicology
Pharmacology

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title = "Mercapturic acid pathway metabolites of xenobiotics: generation of potentially toxic metabolites during enterohepatic circulation",

abstract = "The body detoxifies many xenobiotics via the mercapturic acid pathway (MAP). Unfortunately, in some cases this process provides intermediate metabolites that are substrates for mutagen/toxin-forming reactions - in particular reactive thiols. Jerome Bakke and Jan-{\AA}ke Gustafsson described this process of methylthiolation and the novel metabolic pathway involved. They highlight the increasing load of xenobiotics imposed by industrial processes and the toxicological consequences of their methylthiolated metabolites in individual organisms and the biosphere in general.",

author = "Jerome Bakke and Gustafsson, {Jan {\AA}ke}",

note = "Funding Information: Acknowledgements This investigation was supported by grants from the Swedish Cancer Society and from the Swedish Board for Planning and Co-ordination of Research. Copyright: Copyright 2014 Elsevier B.V., All rights reserved.",

year = "1984",

doi = "10.1016/0165-6147(84)90532-7",

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T1 - Mercapturic acid pathway metabolites of xenobiotics

T2 - generation of potentially toxic metabolites during enterohepatic circulation

AU - Bakke, Jerome

AU - Gustafsson, Jan Åke

N1 - Funding Information: Acknowledgements This investigation was supported by grants from the Swedish Cancer Society and from the Swedish Board for Planning and Co-ordination of Research. Copyright: Copyright 2014 Elsevier B.V., All rights reserved.

PY - 1984

Y1 - 1984

N2 - The body detoxifies many xenobiotics via the mercapturic acid pathway (MAP). Unfortunately, in some cases this process provides intermediate metabolites that are substrates for mutagen/toxin-forming reactions - in particular reactive thiols. Jerome Bakke and Jan-Åke Gustafsson described this process of methylthiolation and the novel metabolic pathway involved. They highlight the increasing load of xenobiotics imposed by industrial processes and the toxicological consequences of their methylthiolated metabolites in individual organisms and the biosphere in general.

AB - The body detoxifies many xenobiotics via the mercapturic acid pathway (MAP). Unfortunately, in some cases this process provides intermediate metabolites that are substrates for mutagen/toxin-forming reactions - in particular reactive thiols. Jerome Bakke and Jan-Åke Gustafsson described this process of methylthiolation and the novel metabolic pathway involved. They highlight the increasing load of xenobiotics imposed by industrial processes and the toxicological consequences of their methylthiolated metabolites in individual organisms and the biosphere in general.

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JF - Trends in Pharmacological Sciences

SN - 0165-6147

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Mercapturic acid pathway metabolites of xenobiotics: generation of potentially toxic metabolites during enterohepatic circulation

Abstract

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