Mercapturic acid pathway metabolites of xenobiotics: generation of potentially toxic metabolites during enterohepatic circulation

Jerome Bakke, Jan-Ake Gustafsson

Research output: Contribution to journalArticle

46 Scopus citations

Abstract

The body detoxifies many xenobiotics via the mercapturic acid pathway (MAP). Unfortunately, in some cases this process provides intermediate metabolites that are substrates for mutagen/toxin-forming reactions - in particular reactive thiols. Jerome Bakke and Jan-Åke Gustafsson described this process of methylthiolation and the novel metabolic pathway involved. They highlight the increasing load of xenobiotics imposed by industrial processes and the toxicological consequences of their methylthiolated metabolites in individual organisms and the biosphere in general.

Original languageEnglish (US)
Pages (from-to)517-521
Number of pages5
JournalTrends in Pharmacological Sciences
Volume5
Issue numberC
DOIs
StatePublished - Jan 1 1984

ASJC Scopus subject areas

  • Toxicology
  • Pharmacology

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