The body detoxifies many xenobiotics via the mercapturic acid pathway (MAP). Unfortunately, in some cases this process provides intermediate metabolites that are substrates for mutagen/toxin-forming reactions - in particular reactive thiols. Jerome Bakke and Jan-Åke Gustafsson described this process of methylthiolation and the novel metabolic pathway involved. They highlight the increasing load of xenobiotics imposed by industrial processes and the toxicological consequences of their methylthiolated metabolites in individual organisms and the biosphere in general.
|Original language||English (US)|
|Number of pages||5|
|Journal||Trends in Pharmacological Sciences|
|State||Published - 1984|
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