Membranous nephropathy in autologous hematopoietic stem cell transplant: Autologous graft-versus-host disease or autoimmunity induction?

Ala Abudayyeh, Luan D. Truong, Laurence H. Beck, Donna M. Weber, Katy Rezvani, Maen Abdelrahim

Research output: Contribution to journalArticle

7 Scopus citations

Abstract

With the increasing utility of hematopoietic stem cell transplantation (SCT) as a treatment for cancer and noncancerous disorders, more challenges and complications associated with SCT have emerged. Renal injury immediately after transplant is common and well understood, but long-termrenal injury is becoming more evident. Chronic graft-versus-host disease (GVHD) is a known long-term complication of SCT, and membranous nephropathy (MN) is emerging as the most common cause of SCTassociated glomerular pathology. In this case report, we present a patient who developed features of anti-PLA2R antibodynegative MN following autologous SCT. The renal injury responded well to steroids and further response to rituximab therapy was noted, suggesting antibody-mediated autoimmune glomerular disease. We also present a review of the literature on autologous GVHD and the role of T and B cells in induction of autoimmunity by SCT.

Original languageEnglish (US)
Pages (from-to)440-444
Number of pages5
JournalClinical Kidney Journal
Volume8
Issue number4
DOIs
StatePublished - Aug 2015

Keywords

  • Anti-PLA2R
  • Autologous stem cell transplant
  • GVHD
  • Membranous nephropathy

ASJC Scopus subject areas

  • Nephrology
  • Transplantation

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