Melanoma incidence rises for children and adolescents: An epidemiologic review of pediatric melanoma in the United States

Mary T. Austin, Yan Xing, Andrea A. Hayes-Jordan, Kevin P. Lally, Janice N. Cormier

Research output: Contribution to journalArticlepeer-review

62 Scopus citations

Abstract

Background/Purpose This study was conducted to determine the influence of age on disease presentation and evaluate the change in pediatric melanoma incidence between 1998 and 2007. Methods We performed a retrospective review of all children ≤ 18 years with cutaneous melanoma who were included in the 2007 National Cancer Institute Surveillance, Epidemiology, and End Results (SEER) database between 1988 and 2007. Results We identified a total of 1447 patients with cutaneous melanoma. The overall average annual melanoma incidence was 5.4 per 1 million children and adolescents in the U.S., which increased throughout the study period. Most patients (89%) were at least 10 years of age (average age 15 years). Melanoma in situ (21%), thin (< 1 mm) lesions (37%), stage I disease (46%), and superficial spreading histology (25%) were common at presentation. Only 1% of patients presented with distant metastases. Preadolescents younger than age 10 were ethnically more diverse and more likely to present with non-truncal primaries and advanced disease (P <.01) compared to adolescents. Conclusions The incidence of pediatric melanoma in the U.S. is increasing. There are significant differences between children and adolescents which suggest age-based inherent differences in the biology of the disease may exist.

Original languageEnglish (US)
Pages (from-to)2207-2213
Number of pages7
JournalJournal of Pediatric Surgery
Volume48
Issue number11
DOIs
StatePublished - Nov 2013

Keywords

  • Age-based differences
  • Incidence
  • Pediatric melanoma

ASJC Scopus subject areas

  • Surgery
  • Pediatrics, Perinatology, and Child Health

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